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Insight into the molecular recognition of human and polar bear pregnane X receptor by three organic pollutants using molecular docking and molecular dynamics simulations.
Environ Int
August 2024
College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, 161006, China. Electronic address:
Article Synopsis
- The study focuses on how the Pregnane X receptor (PXR) in polar bears and humans interacts with certain environmental pollutants, highlighting differences in selectivity and specificity.
- Researchers used methodologies like homology modeling and molecular dynamics simulations to analyze the interactions of three organic pollutants (BPA, chlordane, and toxaphene) with polar bear PXR (pbPXR) and human PXR (hPXR).
- The findings showed that while both PXRs interact with the pollutants similarly, the pollutants affect the dynamics of each receptor differently, particularly impacting key amino acid residues crucial for the binding energy and overall receptor activation.
Pesticide use and inflammatory bowel disease in licensed pesticide applicators and spouses in the Agricultural Health Study.
Environ Res
May 2024
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address:
Article Synopsis
- Pesticide exposure may increase the risk of inflammatory bowel disease (IBD) and has been linked to changes in gut microbiota and inflammation in animals, though there's a lack of extensive human studies on this topic.
- In the Agricultural Health Study, researchers evaluated IBD cases among 68,480 pesticide applicators and their spouses from 1993 to 2022, identifying 454 cases of IBD, with notable patterns in pesticide use.
- Certain organochlorine and organophosphate insecticides, along with some herbicides, showed positive associations with IBD risk, particularly specific chemicals like dieldrin and toxaphene, indicating that exposure to these pesticides may elevate IBD hazards.
Simulated phytoremediation by root exudates of Sudan grass of soil organochlorine pesticides: impact on the rhizosphere microbial community.
Environ Sci Pollut Res Int
November 2023
Department of Food and Biological Engineering, Chengdu University, Chengdu, 610106, Sichuan, China.
The present work aims to study the efficiency of root exudates of Sudan grass on the degradation of organochlorine pesticides (OCPs) and the consequent impact on the microbial and ecological characteristics of the soil, including population composition, quantity dynamics, and community structure. Pot experiments were carried out to study the effect of root exudates on the degradation of OCPs at initial concentrations ranging from 66.67 to 343.
View Article and Find Full Text PDFEnvironmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua).
J Appl Toxicol
December 2023
Department of Biological Sciences, University of Bergen, Bergen, Norway.
Article Synopsis
- Fish in the North Sea and North Atlantic are exposed to high levels of persistent organic pollutants, leading to a study comparing the effects of various halogenated compounds on juvenile Atlantic cod.
- Juvenile male cod were fed mixtures of chlorinated, brominated, and fluorinated compounds for 4 weeks, which resulted in chemical levels in their livers consistent with wild fish in the region.
- The study found that all three compound groups activated the unfolded protein response (UPR) pathway, with key transcription factors being significantly activated, but no additive effects were observed when all three types were combined.
15th Report on Carcinogens.
Rep Carcinog
December 2021
Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Background: The Report on Carcinogens (RoC) is a congressionally mandated, science-based public health document that the National Toxicology Program (NTP) prepares for the U.S. Department of Health and Human Services Secretary.
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