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Application of four pricing models for orphan medicines: a case study for lumasiran.
Orphanet J Rare Dis
December 2024
Medicine for Society, Platform at Amsterdam University Medical Center - University of Amsterdam, Amsterdam, The Netherlands.
Background: The combination of high prices and uncertain effectiveness is a growing challenge in the field of orphan medicines, hampering health technology assessments. Hence, new methods for establishing price benchmarks might be necessary to support reimbursement negotiations. In this study, we applied several pricing models containing cost-based elements to the case of lumasiran for treating primary hyperoxaluria type 1.
View Article and Find Full Text PDFHow can the reform of the activity-based payment system (T2A) help in financing innovative health products?
Therapie
December 2024
Université de Paris, CRESS, AP-HP, 75000 Paris, France.
In France, the short-stay activities of public and private sector healthcare facilities have been financed since 2004 by activity-based pricing (T2A). The principle is to allow for payment determined primarily by the nature and volume of activities. T2A has enabled a major transformation compared to the old financing system, chiefly for public sector facilities that used to operate under a general allocation, and convergence between payment methods in the public and private sectors.
View Article and Find Full Text PDFDeveloping a Strategy to Increase Lung Cancer Screening in Areas of Need.
Popul Health Manag
December 2024
Division of Population Science, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Lung cancer screening (LCS) rates are low, and lung cancer mortality is high in the United States. This report describes a strategy that health systems can use to identify LCS areas of need and engage associated primary care providers and patients in screening. A research team from Jefferson Health (JH), a large, urban health system, used geocoded standardized lung cancer mortality rates (SMRs) to identify zip codes in Philadelphia where lung cancer mortality is high.
View Article and Find Full Text PDFNew Concepts in Circumareolar Mastopexy: The "Star Interlocking Suture"-A Case Series.
Aesthetic Plast Surg
December 2024
Unit of Plastic Surgery, University "Federico II", Via Sergio Pansini, 5, 80131, Naples, Italy.
The circumareolar approach is one of the most popular and versatile in breast surgeries. Nevertheless, this approach usually implies a closure under tension which could lead to areolar distortion, scar widening and hypertrophic scarring. To prevent these complications, different surgical adjustments to this technique have been proposed, such as the Hammond's "Interlocking Gore-Tex suture.
View Article and Find Full Text PDFThe Influencing Factors of Breast Morphological Changes After Dual-Plane Augmentation with Smooth Round Implans: A Correlational Study.
Aesthetic Plast Surg
December 2024
Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.33 Badachu Road, Shijingshan District, Beijing, 100144, China.
Background: Breast morphology is the primary objective indicator for evaluating the outcome of augmentation surgery. Studies have indicated that breast morphology undergoes certain changes during the early postoperative period, which may result in a discrepancy between postoperative outcomes and preoperative design. This study utilized three-dimensional scanning technology and statistical methods to analyze the influencing factors of breast morphology changes, aiming to provide reference for implant selection and preoperative surgical planning.
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