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Cardiopulmonary exercise testing complements both spirometry and nuclear imaging for assessing sarcoidosis stage and for monitoring disease activity.
Sarcoidosis Vasc Diffuse Lung Dis
March 2024
School of Psychology, University of Southampton, Southampton, UK.
Background: Pulmonary sarcoidosis is a systemic disease that can confound established follow-up tools. Pulmonary function tests (PFTs) are recommended in initial and follow-up patient evaluations yet are imperfect predictors of disease progression. The cardiopulmonary exercise test (CPET) is another potentially useful monitoring tool, although previous studies report conflicting findings regarding which variables are altered by the disease.
View Article and Find Full Text PDFAccelerated silicosis in sandblasters: Pathology, mineralogy, and clinical correlates.
Am J Ind Med
March 2024
Department of Pathology, SUNY Upstate Medical University, Syracuse, New York, USA.
Background: With increasing reports of accelerated and acute silicosis, PMF, and autoimmune disease among coal miners and silica-exposed countertop workers, we present previously incompletely-described pulmonary pathology of accelerated silicosis and correlations with mineralogy, radiography, and disease progression in 46 Texas oilfield pipe sandblasters who were biopsied between 1988 and 1995.
Methods: Worker examinations included pulmonary function tests, chest X-ray (CXR), high-resolution computed tomography (HRCT), and Gallium-67 scans. Quantitative mineralogic analysis of pulmonary parenchymal burden of silica, silicates, and metal particles used scanning electron microscopy with energy dispersive x-ray spectroscopy (SEM EDS).
H Derivatives Possessing Picolyl and Picolinate Pendants for Ga Coordination and Ga Radiolabeling.
Inorg Chem
December 2023
CEMCA, Université Brest, UMR 6521, CNRS, 6 avenue Victor le Gorgeu, 29238 Brest, France.
We synthesized, thanks to the regiospecific -functionalization using an orthoamide intermediate, two 1,4,7-triazacyclononane derivatives containing an acetate arm and either a methylpyridine or a picolinic acid group, respectively, H and H, as new Ga chelators for potential use in nuclear medicine. The corresponding Ga complexes were synthesized and structurally characterized in solution by H and C NMR. The [Ga()] complex appears to exist in solution as two diasteroisomeric pairs of enantiomers, as confirmed by density functional theory (DFT) calculations, while for [Ga()], a single species is present in solution.
View Article and Find Full Text PDFUsefulness of gallium-67 scintigraphy for evaluating the histopathological activity in interstitial nephritis.
Clin Exp Nephrol
March 2023
Department of Nephrology, Tokyo Teishin Hospital, 2-14-23 Fujimi, Chiyoda-Ku, Tokyo, Japan.
Background: Interstitial nephritis is a common cause of renal failure. Gallium-67 scintigraphy is reportedly useful for diagnosing interstitial nephritis; however, its ability to assess disease activity remains unknown. We aimed to analyze the relationship between the renal uptake of gallium-67 and the disease activity in interstitial nephritis.
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