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| http://dx.doi.org/10.1038/bjc.1983.258 | DOI Listing |
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Development of a rapid enzymatic quantification method for hyaluronic acid based on the gene-mining of hyaluronate lyase.
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College of Food Science and Engineering, Ocean University of China, Qingdao, 266404, PR China; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, 168 Wenhai Middle Road, Qingdao, 266237, China.
Hyaluronic acid (HA), a vital polysaccharide naturally present in human tissues, is widely utilized in the food, pharmaceutical and cosmetic industries due to its diverse functionalities and bioactivity. Rapid and accurate quantification of HA is essential for the quality control of its products. Enzymatic quantification methods, known for their simplicity and high specificity, were employed for polysaccharide measurement.
View Article and Find Full Text PDFEvolution of SARS-CoV-2 spike trimers towards optimized heparan sulfate cross-linking and inter-chain mobility.
Sci Rep
December 2024
Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Waldeyerstrasse 15, D-48149, Münster, Germany.
The heparan sulfate (HS)-rich extracellular matrix (ECM) serves as an initial interaction site for the homotrimeric spike (S) protein of SARS-CoV-2 to facilitate subsequent docking to angiotensin-converting enzyme 2 (ACE2) receptors and cellular infection. More recent variants, notably Omicron, have evolved by swapping several amino acids to positively charged residues to enhance the interaction of the S-protein trimer with the negatively charged HS. However, these enhanced interactions may reduce Omicron's ability to move through the HS-rich ECM to effectively find ACE2 receptors and infect cells, raising the question of how to mechanistically explain HS-associated viral movement.
View Article and Find Full Text PDFHeparin in sepsis: current clinical findings and possible mechanisms.
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Department of Critical Care Medicine, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Sepsis is a clinical syndrome resulting from the interaction between coagulation, inflammation, immunity and other systems. Coagulation activation is an initial factor for sepsis to develop into multiple organ dysfunction. Therefore, anticoagulant therapy may be beneficial for sepsis patients.
View Article and Find Full Text PDFA label-free fluorescent-hydrogel sensor for heparin detection in diluted whole blood.
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Key Laboratory of Green Chemistry & Technology of MOE, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China.
Heparin is a widely used blood anticoagulant and its monitoring in blood is essential during surgery. Unavoidable interference factors such as blood color and luminescence can interfere with the fluorescence visualization of heparin. Herein, we found a ratiometric fluorescence probe consisting of SYBR green and cresyl violet responsive to heparin mainly based on electrostatic interactions.
View Article and Find Full Text PDFInternational normalized ratio measurement during perioperative anticoagulation bridging with low-molecular-weight heparin in patients undergoing heart valve replacement surgery.
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Laboratory of Hematology, Department of Laboratory Medicine, Radboud UMC, Nijmegen, the Netherlands.
Background: Surgical procedures in anticoagulated patients require specific attention due to increased bleeding risk. Preoperative anticoagulation interruption in high-risk patients is often necessary. Bridging anticoagulation with low-molecular-weight heparin (LMWH) minimizes thromboembolic risk, but its effect on international normalized ratio (INR) measurement is not well established, necessitating careful monitoring and individual assessment.
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