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CRISPR-Edited DPSCs, Constitutively Expressing BDNF Enhance Dentin Regeneration in Injured Teeth.
bioRxiv
December 2024
Department of Oral Biology, College of Dentistry, University of Illinois Chicago, Chicago 60612, IL, USA.
Dental caries is one of the most common health issues worldwide arising from the complex interactions of bacteria. In response to harmful stimuli, desirable outcome for the tooth is the formation of tertiary dentin, a protective reparative process that generates new hard tissue. This reparative dentinogenesis is associated with significant inflammation, which triggers the recruitment and differentiation of dental pulp stem cells (DPSCs).
View Article and Find Full Text PDFDimethyl sulfoxide affects the viability and mineralization activity of apical papilla cells in vitro.
Braz Dent J
December 2024
Department of Restorative Dentistry, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Dimethyl sulfoxide (DMSO) is widely used as an adjuvant in dissolving insoluble compounds in an aqueous medium; however, it can induce significant molecular changes in cells. The possible damages may occur obeying a tissue-specific profile, and the effect on human apical papilla cells (hAPC) remains unknown. Therefore, this study aimed to evaluate DMSO effects on the viability and mineralization activity in hAPC cultures in vitro and to establish standards of maximum concentrations for its use in laboratory routines.
View Article and Find Full Text PDFGlutamine-αKG axis affects dentin regeneration and regulates osteo/odontogenic differentiation of mesenchymal adult stem cells via IGF2 m6A modification.
Stem Cell Res Ther
December 2024
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, Sichuan, China.
Background: Multi-lineage differentiation of mesenchymal adult stem cells (m-ASCs) is crucial for tissue regeneration and accompanied with metabolism reprogramming, among which dental-pulp-derived m-ASCs has obvious advantage of easy accessibility. Stem cell fate determination and differentiation are closely related to metabolism status in cell microenvironment, which could actively interact with epigenetic modification. In recent years, glutamine-α-ketoglutarate (αKG) axis was proved to be related to aging, tumorigenesis, osteogenesis etc.
View Article and Find Full Text PDFOutcome predictors of odontogenic abscesses in the elderly.
Front Oral Health
December 2024
Institute of Medical Microbiology and Virology, University of Oldenburg and Klinikum Oldenburg AöR, Oldenburg, Germany.
Odontogenic infections have a high prevalence and can lead to severe complications. Due to demographic changes, the number of geriatric patients has increased in recent years. The aim of this study was to analyse odontogenic abscesses in elderly patients and to differentiate them from non-elderly patients regarding clinical presentation, bacterial analysis and therapy.
View Article and Find Full Text PDFAssessment of Inflammatory Scores in Severity Prediction for Elderly Patients with Odontogenic Infections.
Dent J (Basel)
November 2024
Discipline of Oral and Maxillo-Facial Surgery, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Odontogenic infections (OIs) can lead to severe complications, especially in elderly patients due to age-related physiological changes and comorbidities. This study aims to evaluate the predictive accuracy of inflammatory scores-APACHE II, CURB-65, SOFA, and NEWS2-in determining the severity of odontogenic infections among elderly patients (>70 years) compared to younger patients (<70 years). A retrospective cohort study was conducted on patients diagnosed with an OI at the Maxillofacial Surgery Department between January 2018 and January 2024.
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