The literature of biology abounds in awe-inspiring acts of iridescent genius. Although a law of nature is phrased in abstract language and is itself devoid of passion and sensibility, the history of its discovery may be an epic worthy of Homer, every page of which bears the stamp of the personality of people. Clearly, scientific truth can be defended by dispassionate logic, but its discovery cannot be promoted this way. The human factor in the creative equation is an important aspect. The discovery of the principles that now form the foundation of developmental craniofacial biology is a story of irony and paradox. Although much progress has been made in many scientific endeavors, many questions regarding craniofacial growth and development remain unanswered. One of the main problems encountered in studies of mammalian growth and development, specifically those dealing with developmental craniofacial biology, has been the apparent lack of application of advances in parallel fields of scientific endeavor. The time seems appropriate for commingling clinical problems with the recently acquired principles of cellular, molecular, and developmental biology.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Protocol for differentiating hematopoietic progenitor cells from human pluripotent stem cells in chemically defined monolayer culture.
STAR Protoc
January 2025
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China. Electronic address:
Human pluripotent stem cells (hPSCs) provide a powerful platform for generating hematopoietic progenitor cells (HPCs) and investigating hematopoietic development. Here, we present a protocol for maintaining hPSCs and inducing their differentiation into HPCs through the endothelial-to-hematopoietic transition (EHT) on vitronectin-coated plates. We outline steps for evaluating the efficiency of HPC generation and assessing their potential to differentiate into various hematopoietic lineages.
View Article and Find Full Text PDFProtocol for microinjection of rapamycin into the zebrafish habenula.
STAR Protoc
January 2025
Laboratory of Developmental Neurobiology, International Institute of Molecular Mechanisms and Machines, 02-247 Warsaw, Poland; Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology in Warsaw, 02-109 Warsaw, Poland. Electronic address:
Mechanistic target of rapamycin complex 1 (mTorC1) activity plays a crucial role in brain development. Here, we present an approach for rapamycin microinjection into the habenula of larval zebrafish to achieve localized inhibition of the mTorC1 pathway and explore the role of mTorC1 in habenula function. We describe steps for performing microinjections and maintaining zebrafish larvae before and after the procedure.
View Article and Find Full Text PDFmiR-449a/miR-340 reprogram cell identity and metabolism in fusion-negative rhabdomyosarcoma.
Cell Rep
January 2025
Translational Cardiomyology Laboratory, Stem Cell and Developmental Biology, Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Histology and Medical Embryology Unit, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Rome, Italy. Electronic address:
Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma, arises in skeletal muscle and remains in an undifferentiated state due to transcriptional and post-transcriptional regulators. Among its subtypes, fusion-negative RMS (FN-RMS) accounts for the majority of diagnoses in the pediatric population. MicroRNAs (miRNAs) are non-coding RNAs that modulate cell identity via post-transcriptional regulation of messenger RNAs (mRNAs).
View Article and Find Full Text PDF"Age of risk" shapes simpler multimodal communication in the juvenile plains zebra (Equus quagga).
Commun Biol
January 2025
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
Juveniles occupy a different social niche than adults, engaging in a smaller diversity of social contexts and perceiving greater social risks. Either or both of these factors may influence the form communication takes in immaturity and its developmental trajectory. We investigated the relative influence of these social forces on the development of multimodal communication in plains zebras (Equus quagga).
View Article and Find Full Text PDF…But Words Will Never Hurt Me.
Eur Urol
January 2025
Eastern Health Clinical School, Monash University, Melbourne, Australia; Cancer Services, Eastern Health, Melbourne, Australia; Biomedicine Discovery Institute Cancer Program, Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!