The treatment of first and second generation patients, having been traumatized by social catastrophes (like German concentration camps), puts a heavy burden on the therapist. To overcome this, the therapist must clearly realize what goes on in himself (countertransference) to avoid unsuitable interpretations and acting out. This counts even more if the therapist himself has undergone social trauma. Two case studies are included, which illustrate how the author could further the analytic process. Especially with masochistic-regressive patients the analyst has to accept and use his temporary identification.
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PLoS One
January 2025
Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Objective: This study aims to construct a training course and quality evaluation index system for chronic disease Medication Therapy Management service (MTMs) that is suitable for China's national conditions. It seeks to provide tools and a scientific foundation for assessing the quality of MTMs training.
Methods: Drawing from domestic and international literature and combining with the practice of chronic disease medication management by Chinese pharmacists, a preliminary framework for the evaluation index system was established.
PLoS One
January 2025
Laboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, Casablanca, Morocco.
Cognitive dysfunction in Alzheimer's disease results from a complex interplay of various pathological processes, including the dysregulation of key enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and monoamine oxidase B (MAO-B). This study proposes and designs a series of novel molecules derived from 8-hydroxyquinoline (Azo-8HQ) as potential multi-target lead candidates for treating AD. An exhaustive in silico analysis was conducted, encompassing docking studies, ADMET analysis, density functional theory (DFT) studies, molecular dynamics simulations, and subsequent MM-GBSA calculations to examine the pharmacological potential of these molecules with the specific targets of interest.
View Article and Find Full Text PDFPsychol Bull
January 2025
Department of Kinesiology, University of North Carolina at Greensboro.
This meta-review provides the first meta-analytic evidence from published meta-analyses examining the effectiveness of acute exercise interventions on cognitive function. A multilevel meta-analysis with a random-effects model and tests of moderators were performed in R. Thirty systematic reviews with meta-analyses (383 unique studies with 18,347 participants) were identified.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
January 2025
Laboratory of Design and Development of Innovative Knitted Textiles and Garments, Department of Industrial Design and Production Engineering, University of West Attica, 12244, Egaleo, Attica, Greece.
This study investigates the production of high-purity cellulose pulp from peach (Prunus persica) fruit wastes generated during the processing of a Greek compote and juice production industry. A three-step chemical process is used, including alkaline treatment with NaOH, organic acid (acetic and formic) treatment, and hydrogen peroxide treatment, with the goal of cellulose extraction and purification. A fractional factorial design optimized reagent levels, revealing the strong influence of NaOH concentration on α-cellulose content and degree of polymerization.
View Article and Find Full Text PDFJ Chem Inf Model
January 2025
Analytical Research & Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
The screening of chemical libraries is an essential starting point in the drug discovery process. While some researchers desire a more thorough screening of drug targets against a narrower scope of molecules, it is not uncommon for diverse screening sets to be favored during the early stages of drug discovery. However, a cost burden is associated with the screening of molecules, with potential drawbacks if particular areas of chemical space are needlessly overrepresented.
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