The possible applications of computer-assisted static perimetry are examined after five years of personal controlled studies of different types of computerized perimeters. The common advantage of all computer-assisted perimeters is the elimination of the influence of the perimetrist on the results. However, some perimeters are fully computer-assisted and some are only partially so. Even after complete elimination of the perimetrist's influence, some physiological and psychological influences remain due to the patient and will cause fluctuations of the results. In perimeters, the density of the grid and the adaptive strategy of exact threshold measurement are important in obtaining reproducible results. A compromise between duration of the test and exactness has to be found. The most acceptable compromise seems to be an uneven distribution of stimuli, which form a denser grid in areas of special interest and a wider grid in areas less likely to be involved, combined with exact threshold measurements only in suspicious areas. Multiple stimulus presentation is not adequate. High sensitivity of screening is not a great advantage, unless combined with a high specificity. We have shown that using the same stimulus luminosity for center and periphery (a nonadaptive strategy) produces nonspecific results. Only an adaptive strategy can result in high sensitivity and specificity. Adaptive strategy means that the luminosity of the stimulus is adapted to the individual threshold curve of the visual field. In addition, the exact individual thresholds are bracketed by small up and down steps of variation in luminosity. In some cases, scanning programs with two levels of adaptation can be sufficient. The user of modern perimeters must understand such terms as: asb, dB, presentation time, and diameter of stimuli. Projection of stimuli is preferred to light emitting diodes or glass fiber optics. The programs (software) of the modern instruments are of the greatest importance, because the clinical experience that the perimetrist had to acquire in previous manual perimetry is incorporated in these programs. In the Octopus perimeter a delta program is available that differentiates patient fluctuations that may be insignificant from directed significant alterations of the field which might require alteration of therapy. The programs are listed for different computer-assisted perimeters, and their choice is described. The costs of the perimeters are also given. Many controlled clinical studies are quoted briefly where they are useful for understanding the discussion. A brief chapter deals with the reliability of the perimetric test.(ABSTRACT TRUNCATED AT 400 WORDS)
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Chaos
January 2025
Agricultural and Ecological Research Unit, Indian Statistical Institute, 203 B. T. Road, Kolkata 700108, India.
Experimental observations and field data demonstrated that predators adapt their hunting strategies in response to prey abundance. While previous studies explored the impact of predation risk on predator-prey interactions, the impact of symbiotic relationships between fear-affected prey and non-prey species on system dynamics remains unexplored. This study uses a mathematical approach to investigate how different symbiotic relationships govern system dynamics when predators adapt to prey availability.
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January 2025
Unitat de Recerca i Innovació, Gerència d'Atenció Primària i a la Comunitat de la Catalunya Central, Institut Català de la Salut, Sant Fruitós de Bages, Spain.
Background: The COVID-19 pandemic reshaped social dynamics, fostering reliance on social media for information, connection, and collective sense-making. Understanding how citizens navigate a global health crisis in varying cultural and economic contexts is crucial for effective crisis communication.
Objective: This study examines the evolution of citizen collective sense-making during the COVID-19 pandemic by analyzing social media discourse across Italy, the United Kingdom, and Egypt, representing diverse economic and cultural contexts.
Blood
January 2025
The Christie NHS Foundation Trust, United Kingdom.
Follicular lymphoma is the most common subtype of indolent lymphoma. Despite multiple trials over the past decade showing improved progression-free survival with new first-line therapeutic strategies -such as anti-CD20 maintenance therapy and new glycoengineered anti-CD20 antibodies- no standardized approach has been widely adopted in routine clinical practice. Several factors may explain this, including the increased incidence of infectious adverse events associated with these therapies, particularly during the COVID-19 pandemic, and the lack of overall survival benefit despite long-term follow-up.
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School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, P. R. China.
We demonstrate here an efficient and facile Ni-catalyzed electrochemical cross-electrophile thiolation approach for readily available alkyl alcohols with pyridyl thioesters. This C(sp)-S bond-forming modular strategy displays extensive substrate adaptability and good functional group tolerance, which allows the production of a range of alkyl sulfides with specific chemoselectivity. Furthermore, the potential applications of this methodology are illustrated by last-stage modification of bioactive molecules and sulfinylative cross-couplings.
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January 2025
Universidade Estadual de Campinas, Faculdade de Enfermagem, Campinas, SP, Brazil.
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