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First-Line Mobocertinib Versus Platinum-Based Chemotherapy in Patients With Exon 20 Insertion-Positive Metastatic Non-Small Cell Lung Cancer in the Phase III EXCLAIM-2 Trial.
J Clin Oncol
January 2025
Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Chinese University of China, Shatin, Hong Kong Special Administrative Region, China.
Purpose: Mobocertinib is an oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that targets exon 20 insertion (ex20ins) mutations in non-small cell lung cancer (NSCLC). This open-label, phase III trial (EXCLAIM-2: ClinicalTrials.gov identifier: NCT04129502) compared mobocertinib versus platinum-based chemotherapy as first-line treatment of ex20ins+ advanced/metastatic NSCLC.
View Article and Find Full Text PDFFatuamide A, a Hybrid PKS/NRPS Metallophore from a sp. Marine Cyanobacterium Collected in American Samoa.
J Nat Prod
January 2025
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093, United States.
A structurally novel metabolite, fatuamide A (), was discovered from a laboratory cultured strain of the marine cyanobacterium sp., collected from Faga'itua Bay, American Samoa. A bioassay-guided approach using NCI-H460 human lung cancer cells directed the isolation of fatuamide A, which was obtained from the most cytotoxic fraction.
View Article and Find Full Text PDFSelf-Foldable Three-Dimensional Biointerfaces by Strain Engineering of Two-Dimensional Layered Materials on Polymers.
ACS Appl Mater Interfaces
January 2025
School of Computation, Information and Technology, Technical University of Munich, Garching 85748, Germany.
Two-dimensional layered materials (2DLMs) have received increasing attention for their potential in bioelectronics due to their favorable electrical, optical, and mechanical properties. The transformation of the planar structures of 2DLMs into complex 3D shapes is a key strategic step toward creating conformal biointerfaces with cells and applying them as scaffolds to simultaneously guide their growth to tissues and enable integrated bioelectronic monitoring. Using a strain-engineered self-foldable bilayer, we demonstrate the facile formation of predetermined 3D microstructures of 2DLMs with controllable curvatures, called microrolls.
View Article and Find Full Text PDFImpact of Siberian Wildfires on Ice-Nucleating Particle Concentrations over the Northwestern Pacific.
Environ Sci Technol
January 2025
Research Institute for Global Change, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Yokohama, Kanagawa 236-0001, Japan.
Ice-nucleating particles (INPs) significantly influence aerosol-cloud precipitation interactions at regional and global scales. However, information regarding the concentrations and origins of INPs over the open ocean, particularly at high latitudes, remains insufficient due to access difficulties. In this study, we investigated the concentrations and origins of INPs over the western North Pacific to the Arctic Ocean through ship-borne observations conducted in the early autumn of 2016.
View Article and Find Full Text PDFExotic Synchronization in Continuous Time Crystals Outside the Symmetric Subspace.
Phys Rev Lett
December 2024
Indian Institute of Technology, Department of Physics, -Bombay, Powai, Mumbai 400076, India.
Exploring continuous time crystals (CTCs) within the symmetric subspace of spin systems has been a subject of intensive research in recent times. Thus far, the stability of the time-crystal phase outside the symmetric subspace in such spin systems has gone largely unexplored. Here, we investigate the effect of including the asymmetric subspaces on the dynamics of CTCs in a driven dissipative spin model.
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