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Analysis of Genitourinary Rhabdomyosarcoma in Phase 3 clinical trials.
World J Urol
December 2024
Department of Urology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 668, Rochester, NY, 14642, USA.
Purpose: Pediatric Rhabdomyosarcoma (RMS) is a morbid and often lethal condition characterized by a paucity of clinical data. Beyond a detailed risk categorization system, it is unclear if genitourinary (GU) sites (bladder/prostate, paratesticular, female organs) have outcomes distinct from non-GU sites. This study pools primary data from phase-3 clinical trials involving pediatric RMS to evaluate this question.
View Article and Find Full Text PDFRole of Fine Needle Aspiration Cytology in Paratesticular Neoplasms-A Case Reports-Based Systematic Review.
Diagn Cytopathol
December 2024
Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Bibinagar, Telangana, India.
Introduction: The cytology features of neoplastic paratesticular lesions are mostly documented as case reports. Thus, we conducted a case report-based literature review to identify the characteristics of paratesticular neoplasms and tried to determine the significance of FNAC in these tumors.
Methods And Materials: The studies were searched using PubMed and Scopus.
Cancer in Multilineage Mosaic RASopathies due to Pathogenic Variants in HRAS or KRAS: A Systematic Review and Meta-analysis.
Clin Cancer Res
November 2024
Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
Article Synopsis
- The study aims to assess the cancer risks associated with multi-lineage mosaic RASopathies that have pathogenic variants in HRAS or KRAS.
- A systematic review was conducted, identifying 69 patients, revealing a 17% cancer prevalence among them, with various types, notably rhabdomyosarcoma.
- Findings indicate a 20% cumulative cancer incidence by age 20 and emphasize the importance of close monitoring for rhabdomyosarcoma in young children and skin cancer in adults with these conditions.
Effect of emergent nephrostomy on long-term total and split renal function in patients with upper urinary tract obstruction due to pelvic malignant tumors.
Pediatr Surg Int
August 2024
Department of Pediatric Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba, 260-8677, Japan.
Article Synopsis
- This study explored how nephrostomies affect total renal function (TRF) and split renal function (SRF) in patients with pelvic tumors that cause upper urinary tract obstruction (UUTO).
- Researchers analyzed data from patients treated between 2000 and 2022, comparing those who received nephrostomies to those who did not.
- Results indicated that nephrostomy improved estimated glomerular filtration rate (eGFR) in treated patients, while those without the procedure showed no improvement, suggesting that nephrostomies may enhance renal outcomes in this context.
Mimicry of Rhabdomyosarcoma by Tonsillar Actinomycosis: Case Report.
Medicina (Kaunas)
July 2024
Specialization in Internal Medicine, Department of Health, Universidad Santiago de Cali, Cali 5183000, Colombia.
Article Synopsis
- * A 51-year-old male with a history of cancer initially presented with severe pain and headaches, mistakenly thought to be a cancer recurrence, but was ultimately diagnosed with actinomycosis after thorough examinations.
- * Treatment involved long-term antibiotic therapy, highlighting the importance of recognizing actinomycosis in patients with complex medical histories to ensure timely and appropriate care.
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