The inhibitory effect of synthetic elastase inhibitor was studied in experimental emphysema. The development of emphysema was totally prevented by this substance. According to the authors' opinion the administration of synthetic elastase inhibitors can be considered as a new possibility in the treatment of pulmonary emphysema.

Download full-text PDF

Source

Publication Analysis

Top Keywords

elastase inhibitor
8
pulmonary emphysema
8
synthetic elastase
8
protective specific
4
specific elastase
4
inhibitor experimental
4
experimental pulmonary
4
emphysema
4
emphysema inhibitory
4
inhibitory synthetic
4

Similar Publications

Neutrophil elastase (NE) is released by activated neutrophils during an inflammatory response and exerts proteolytic activity on elastin and other extracellular matrix components. This protease is rapidly inhibited by the plasma serine protease inhibitor alpha-1-antitrypsin (AAT), and the importance of this protective activity on lung tissue is highlighted by the development of early onset emphysema in individuals with AAT deficiency. As a serpin, AAT presents a surface-exposed reactive centre loop (RCL) whose sequence mirrors the target protease specificity.

View Article and Find Full Text PDF

Neutrophil Extracellular Traps Drive Kidney Stone Formation.

Kidney Dis (Basel)

November 2024

Department of Geriatric Urology, Xiangya International Medical Center, Xiangya Hospital, Central South University, Changsha, PR China.

Introduction: This study aims to explore the contribution of neutrophil extracellular traps (NETs) to kidney stones.

Methods: The microarray data from GSE73680 and bioinformatic analysis were applied to identify differentially expressed genes in patients with kidney stones. A rat model of kidney stones was established through ethylene glycol and ammonium chloride administration.

View Article and Find Full Text PDF

Inhibiting CFTR through inh-172 in primary neutrophils reveals CFTR-specific functional defects.

Sci Rep

December 2024

Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.

The lungs of people with cystic fibrosis (PwCF) are characterized by recurrent bacterial infections and inflammation. Infections in cystic fibrosis (CF) are left unresolved despite excessive neutrophil infiltration. The role of CFTR in neutrophils is not fully understood.

View Article and Find Full Text PDF

Anti-wrinkle activity of the ethanol extract of Aronia melanocarpa for development of the cosmeceutical ingredients.

Cell Mol Biol (Noisy-le-grand)

November 2024

Department of Biological and Chemical Engineering, Hongik University, Sejong 30016, Republic of Korea.

Despite the abundance of natural biological resources in Aronia melanocarpa, there is still insufficient research specifically exploring the potential for developing cosmeceutical compositions utilizing this plant. To develop the ingredient with the cosmeceutical function, the anti-wrinkle effect of the ethanol extract of A. melanocarpa was investigated.

View Article and Find Full Text PDF

Egg Protein Compositions over Embryonic Development in Ticks.

Animals (Basel)

November 2024

College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.

Tick eggs contain a series of proteins that play important roles in egg development. A thorough characterization of egg protein expression throughout development is essential for understanding tick embryogenesis and for screening candidate molecules to develop novel interventions. In this study, eggs at four developmental stages (0, 7, 14, and 21 incubation days) were collected, and their protein extraction was profiled using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!