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Perfluorohexane Sulfonic Acid Disrupts the Immune Microenvironment for Spermatogenesis by Damaging the Structure of the Blood-Testis Barrier in Mice.
Adv Sci (Weinh)
January 2025
State Key Laboratory of Reproductive Medicine and Offspring Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Perfluorohexane sulfonic acid (PFHxS) is extensively used in waterproof coatings and fire-fighting foams, and several studies have found it to be a potential health hazard, but there is still unknown about its effects on spermatogenesis. Our results showed that PFHxS-treated mice have significant reproductive toxicity, including a decrease in sperm count and motility, and the levels of sex hormones (P < 0.05).
View Article and Find Full Text PDFKnowledge of obstetric danger signs and its associated factors among husbands residing in the Raya Kobo district, Ethiopia.
Front Public Health
January 2025
School of Midwifery, College of Health Sciences, Woldia University, Woldia, Ethiopia.
Background: The term "danger signs" refers to any symptoms or indicators that suggest a pregnant woman may be at risk during pregnancy. Mothers are often burdened with responsibilities, and the majority of them do not even receive treatment for potential complications, which can ultimately lead to the loss of their lives. This situation highlights the barriers that prevent them from being properly prepared for potential risks.
View Article and Find Full Text PDFGlobal Harmonization of Biosimilar Development by Overcoming Existing Differences in Regional Regulatory Requirements - Outcomes of a Descriptive Review.
Ther Innov Regul Sci
January 2025
, Highland Park, NJ, USA.
Global harmonization of biosimilar developmental requirements will facilitate development leading to increased patient and societal benefits. However, there are several technical and regulatory hurdles that must be addressed to harmonize the regulatory requirements in different countries and regions. At times, there is a requirement for use of locally sourced reference product, forcing biosimilar developers to repeat analytical or clinical comparability studies against reference product batches sourced from within a given country.
View Article and Find Full Text PDFRANK/RANKL Signaling Pathway in Breast Development and Cancer.
Adv Exp Med Biol
January 2025
Molecular Oncology, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
RANK pathway has attracted increasing interest as a promising target in breast cancer, given the availability of denosumab, an anti-RANKL drug. RANK signaling mediates progesterone-driven regulation of mammary gland development and favors breast cancer initiation by controlling mammary cell proliferation and stem cell fate. RANK activation promotes luminal mammary epithelial cell senescence, acting as an initial barrier to tumorigenesis but ultimately facilitating tumor progression and metastasis.
View Article and Find Full Text PDFDigital Age Transformation in Patient-Physician Communication: 25-Year Narrative Review (1999-2023).
J Med Internet Res
January 2025
University of Nebraska at Omaha, Omaha, NE, United States.
Background: The evolution of patient-physician communication has changed since the emergence of the World Wide Web. Health information technology (health IT) has become an influential tool, providing patients with access to a breadth of health information electronically. While such information has greatly facilitated communication between patients and physicians, it has also led to information overload and the potential for spreading misinformation.
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