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The relationship between "microbiota-gut-brain" axis and depression: chronic stress-induced inflammation.
Physiol Behav
March 2025
College of biological and pharmaceutical engineering, West Anhui University, Lu'an, 237012, China; Anhui Traditional Chinese Medicine Ecological Agricultural Engineering Research Center, Lu'an, 237012, China.
This study aims to investigate the pathogenesis of depression in mice using the chronic unpredictable mild stress (CUMS) model, with a particular focus on the changes in inflammatory gene networks and inflammatory factor levels under the condition of gut microbiota dysbiosis. The results indicate that CUMS-induced mice exhibited significant depressive-like behaviors. Specifically, they displayed reduced sucrose intake in the sucrose preference test, decreased central area distance and time in the open field test, and reduced percentage of entries and time spent in the open arm in the elevated plus maze test.
View Article and Find Full Text PDFLink between gut damage and neurotoxicity with gender differences in zebrafish: Dibutyl phthalate-driven microbiota dysbiosis as a possible major cause.
Sci Total Environ
March 2025
School of Resources and Environment, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:
Among plasticizers, dibutyl phthalate (DBP) is widely used in in industry, posing significant health risks to aquatic organisms. In this study, adult male and female zebrafish were exposed to 0 and 30 μg/L DBP for 15 days. Behavioral monitoring, immunofluorescence, protein immunoblotting, and high-throughput sequencing were used to investigate the critical role of the gut microbiome in DBP-induced dysfunction of the zebrafish gut-brain axis.
View Article and Find Full Text PDFDisturbances in the gut microbiota potentially associated with metabolic syndrome among patients living with HIV-1 and on antiretroviral therapy at Bafoussam Regional Hospital, Cameroon.
Diabetol Metab Syndr
March 2025
Division of Molecular Biology, Indian Council of Medical Research - National Institute of Translational Virology and AIDS Research, 73 G MIDC Bhosari, Pune, 411026, India.
Background: This study investigates the gut microbiota components associated with metabolic syndrome in patients living with HIV-1 at Bafoussam Regional Hospital, West Cameroon, it focuses on gastrointestinal mucosal barrier disruption and dysbiosis, and their effects on persistent inflammation and metabolic disorders.
Methods: A pilot study was conducted involving fourteen patients living with HIV-1. The patients were divided into two groups of seven in each group.
Gut Microbiome dysbiosis and immune activation correlate with somatic and neuropsychiatric symptoms in COVID-19 patients.
J Transl Med
March 2025
Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA.
Background: Infection with SARS-CoV-2, the virus responsible for COVID-19, can lead to a range of physical symptoms and mental health challenges, including stress, anxiety, and depression. These effects are particularly pronounced in hospitalized patients, likely due to the virus's direct and indirect impact on the nervous system. Gut dysbiosis, an imbalance in the gut microbiome, has been implicated in immune dysfunction and chronic inflammation in COVID-19 patients.
View Article and Find Full Text PDFDiversity and functional features of the root-associated bacteriome are dependent on grapevine susceptibility to Plasmopara viticola.
Environ Microbiome
March 2025
Université de Reims Champagne-Ardenne, INRAE, RIBP, USC 1488, Reims, 51100, France.
Background: Plant health depends on beneficial interactions between the roots and their microbiomes. Despite recent progress on the role of the grapevine microbiome, the taxonomic identity and functional traits of microbial taxa specific to healthy or Plasmopara viticola-diseased plants, as well as to the susceptible or resistant cultivar are unknown. Using metabarcoding and shotgun metagenomics sequencing, we investigated the effect of downy mildew on the root-associated microbiome (rhizospheric soil, rhizoplane and endosphere) of 41B-grafted susceptible cultivar (Chardonnay) and resistant interspecific hybrid (Voltis) at flowering and veraison stages.
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