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Comparing sputum, nasopharyngeal swabs, and combined samples for respiratory bacterial detection using multiplex PCR.
Microbiol Spectr
January 2025
Department of Laboratory Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea.
Unlabelled: Respiratory tract infections are major global health issues that require rapid and accurate diagnostic methods. Multiplex quantitative PCR (qPCR) is commonly used for pathogen detection in respiratory samples. However, the optimal specimen selection for detecting bacterial pathogens is not well-explored.
View Article and Find Full Text PDFState-of-the-Art Review: Diagnosis and Management of Spinal Implant Infections.
Clin Infect Dis
December 2024
Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Spinal implant infections are a serious complications of instrumented spinal fusion surgeries, carrying high morbidity and complex management challenges. Early postoperative infections may manifest with wound-healing issues, back pain, and fevers. Magnetic resonance imaging (MRI) is the preferred imaging modality, but can be limited by metal artifacts.
View Article and Find Full Text PDFLonidamine, a Novel Modulator for the BvgAS System of Bordetella Species.
Microbiol Immunol
December 2024
Department of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
The Gram-negative bacteria Bordetella pertussis, B. parapertussis, and B. bronchiseptica cause respiratory diseases in various mammals.
View Article and Find Full Text PDFChildhood Respiratory Illnesses Before and After COVID-19 Pandemic Restrictions.
Cureus
November 2024
Pediatric Emergency Medicine, Loma Linda University Medical Center, Loma Linda, USA.
Introduction With the COVID-19 pandemic, multiple studies described a significant drop in common respiratory viruses in children with the lockdown and restrictions. With the lifting of pandemic precautions, we had the ability to observe new patterns of respiratory illnesses in children and emergency department visits. Materials and methods We studied all respiratory nucleic acid amplification test results in emergency patients from a large metropolitan children's hospital from the years 2018 to 2023.
View Article and Find Full Text PDFArticle Synopsis
- Whooping cough, caused by Bordetella pertussis and Bordetella parapertussis, is highly contagious and particularly dangerous for infants, with Africa having the highest incidence and mortality rates.
- A study conducted in Abidjan from April 2019 to July 2021 involved infants with coughs and their household contacts, finding a significant number of infections among both infants and family members.
- Results showed high circulation of pertussis in the community, emphasizing the need to address obstacles to accessing recommended booster vaccinations as suggested by the WHO.
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