Levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat plasma were measured by radioimmunoassay and found to exhibit a circadian rhythm that parallelled the normal rhythm for corticosterone. The maximal plasma levels of both substances were observed to occur at about 1700h. The lowest concentrations of DSIP-LI and corticosterone were detected at 2400h and 1000h, respectively. Exposure to constant levels of illumination abolished the rhythm of DSIP-LI. It is possible that the temporal parallelism between the levels of DSIP-LI and corticosterone may represent a functional relationship between both compounds.
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