Experiments on rabbits, white rats and mice with experimental tetanus intoxication were made to study and compare the efficacy of the tetanus antitoxin Diaferm-3 and its Fab'-fragments. Fab'-fragments were discovered to be more effective in the early stages of intoxication, when injected in fairly high doses and partially when administered intracarotidally. Intracisternal injection of the antitoxin Diaferm-3 appeared the most effective for the treatment of demonstrable intoxication.

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Experiments on rabbits, white rats and mice with experimental tetanus intoxication were made to study and compare the efficacy of the tetanus antitoxin Diaferm-3 and its Fab'-fragments. Fab'-fragments were discovered to be more effective in the early stages of intoxication, when injected in fairly high doses and partially when administered intracarotidally. Intracisternal injection of the antitoxin Diaferm-3 appeared the most effective for the treatment of demonstrable intoxication.

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Immunochemically pure tetanus antitoxin obtained from enzyme-treated horse serum is less reactogenic and anaphylactogenic and possesses higher therapeutic properties than antitoxin purified by nonspecific physico-chemical methods and containing ballast antigens. Due to its increased persistence in the recipient's body, the immunochemically pure antitoxin induces passive immunity in considerably lower doses than the preparations purified by the method "Diaferm-3".

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The treatment of experimental tetanus intoxication in 120 rabbits by the intrathecal injection of antitoxins revealed that the therapeutic effect was directly proportional to the dose of antitoxins, expressed in antitoxic units. The maximum effect (the survival rate 78.6%) was obtained by the injection of antitoxins purified on immunoadsorbents and containing no admixtures.

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Antitoxic therapeutic sera produced by the method "Diaferm-3" (devised at the Institute of Epidemiology and Microbiology of the USSR Academy of Medical Sciences) are contaminated in the process of production with group-specific substances and extraneous enzymes contained in crude preparations of swine pepsin. These ballast substances have a negative influence on the process of purification and the stability of antitoxin during the storage of the sera and constitute one of the reasons of their high reactogenicity.

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Experiments were conducted on 100 rabbits with asscending, hematogenic and cerebral tetanus caused by the administration of tetanus toxin (1 Dcl). The therapeutic efficacy of "Diaferm-3" antitoxin was compared depending on the route--intracysternal or intralumbar--of its administration (400 IU/kg). Intracysternal antitoxin administration proved to be thrice as effective as the intralumbar one (31.

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