Fifty three patients having fever of unknown origin according to the criterion of Petersdorf and Beeson were studied. Malignant tumors were found to be the cause in 21 per 100 of the cases. The authors indicate the time required to make an etiologic diagnosis, and the procedures employed for it.
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J Bacteriol
January 2025
Department of Microbiology, University of Washington, Seattle, Washington, USA.
The mammalian gut microbiome is a dense and diverse community of microorganisms that reside in the distal gastrointestinal tract. In recent decades, the bacterial members of the gut microbiome have been the subject of intense research. Less well studied is the large community of bacteriophages that reside in the gut, which number in the billions of viral particles per gram of feces, and consist of considerable unknown viral "dark matter.
View Article and Find Full Text PDFNat Commun
January 2025
CIRAD, UMR AGAP Institut, Montpellier, France.
Hybridization between wild Musa species and subspecies from Southeast Asia is at the origin of cultivated bananas. The genomes of these cultivars are complex mosaics involving nine genetic groups, including two previously unknown contributors. This study provides continuous genome assemblies for six wild genetic groups, one of which represents one of the unknown ancestor, identified as M.
View Article and Find Full Text PDFNature
January 2025
School of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Tissue-resident memory CD8 T (T) cells provide protection from infection at barrier sites. In the small intestine, T cells are found in at least two distinct subpopulations: one with higher expression of effector molecules and another with greater memory potential. However, the origins of this diversity remain unknown.
View Article and Find Full Text PDFNature
January 2025
Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Female mammalian cells have two X chromosomes, one of maternal origin and one of paternal origin. During development, one X chromosome randomly becomes inactivated. This renders either the maternal X (X) chromosome or the paternal X (X) chromosome inactive, causing X mosaicism that varies between female individuals, with some showing considerable or complete skew of the X chromosome that remains active.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
The Royal Melbourne Hospital, Parkville, Victoria, Australia.
Aortic angiosarcomas are extremely rare and difficult to diagnose. Here, we report a case of persistent pain and fever of unknown origin, culminating in the diagnosis of aortic epithelioid angiosarcoma at the site of a previous Dacron aortic graft.
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