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D1 Receptor Functional Asymmetry at Striatonigral Neurons: A Neurochemical and Behavioral Study in Male Wistar Rats.
J Neurosci Res
January 2025
Departamento de Fisiología, Biofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de Mexico, Mexico.
Lateralization of motor behavior, a common phenomenon in humans and several species, is modulated by the basal ganglia, a site pointed out for the interhemispheric differences related to lateralization. Our study aims to shed light on the potential role of the striatonigral D1 receptor in functional asymmetry in normal conditions through neurochemical and behavioral means. We found that D1 receptor activation and D1/D3 receptor coactivation in striatonigral neurons leads to more cAMP production by adenylyl cyclase in the striatum and GABA release in their terminals in the right hemisphere compared to the left.
View Article and Find Full Text PDFMicrostructural Degeneration of the Corpus Callosum in Parkinson's Disease with Unilateral Onset: A Free-Water Imaging Study.
ACS Chem Neurosci
December 2024
Department of Radiology, The Second Affiliated Hospital, Zhejiang University of Medicine, Hangzhou 310009, China.
Article Synopsis
- Motor symptom laterality in Parkinson's Disease (PD) impacts both motor and nonmotor symptoms, potentially altering patient prognosis, with compensatory mechanisms in the brain's dominant hemisphere playing a key role.
- This study investigated the microstructural changes in the corpus callosum (CC), the brain's main connector between hemispheres, in 201 right-handed PD patients (split between left- and right-onset) compared to 100 healthy controls using advanced imaging techniques.
- Findings revealed reduced free water and fractional anisotropy, along with increased mean diffusivity in the CC of patients with left-side PD onset, highlighting the relationship between brain structure and disease symptoms.
Asymmetric intra and inter-hemispheric subcellular rat brain correlation of arginyl-aminopeptidase activity during development and aging.
Brain Res
December 2024
Department of Physiology, Faculty of Medicine, University of Granada, Granada 18071, Spain.
The functional significance of brain asymmetry is still largely unknown. Studying the level of correlation of neuropeptide-degrading activities between subcellular fractions such as synaptosomal, of the left and right hemispheres of male rats during development and aging could provide relevant data on their functional role during these periods. The present study analyzes the level of correlation of a enkephalin- or angiotensin III-degrading activity, such as membrane-bound arginyl-aminopeptidase activity (M-B ArgAP) between the left versus right homogenate and/or synaptosomal subcellular fractions obtained and processed independently from both brain hemispheres during development and aging.
View Article and Find Full Text PDFGlobal and Regional Sex-Related Differences, Asymmetry, and Peak Age of Brain Myelination in Healthy Adults.
J Clin Med
November 2024
Department of Radiology, School of Medicine, South Lake Union Campus, University of Washington, 850 Republican St., Seattle, WA 98109, USA.
The fundamental question of normal brain myelination in human is still poorly understood. : Age-dependent global, regional, and interhemispheric sex-related differences in brain myelination of 42 (19 men, 23 women) healthy adults (19-67 years) were explored using the MRI method of fast macromolecular fraction (MPF) mapping. : Higher brain myelination in males compared to females was found in global white matter (WM), most WM tracts, juxtacortical WM regions, and putamen.
View Article and Find Full Text PDFDuring the second recovery phase of the 13-14 March 2022 storm, intense high-latitude neutral mass density spikes are detected by satellites at ∼500 km in both hemispheres. These density spikes, accurately modeled by the Global Ionospheric Thermosphere Model (GITM), are identified as high-latitude neutral mass density anomalies (HDAs). The GITM simulation indicates that these HDAs, which extends over the polar region, are important features in high-latitude neutral density.
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