AI Article Synopsis

  • A 3-month-old boy experienced acute neurological dysfunction linked to the use of domperidone, an anti-emetic drug.
  • Initially, it was thought that domperidone wouldn't cause neurological issues.
  • This case, along with three others, highlights the potential for adverse neurological reactions from domperidone.

Article Abstract

The authors relate the observation of a 3-month-old boy who showed acute neurological dysfunction of the extrapyramidal system secondary to the administration of domperidone, a new anti-emetic drug. This drug was first believed not to provoke neurological dysfunction. Yet, this and three other published cases document the possibility of adverse neurological reactions due to domperidone administration.

Download full-text PDF

Source

Publication Analysis

Top Keywords

domperidone administration
8
neurological dysfunction
8
acute extrapyramidal
4
extrapyramidal dysfunction
4
dysfunction domperidone
4
administration report
4
report case
4
case authors
4
authors relate
4
relate observation
4

Similar Publications

Article Synopsis
  • A study examined the effectiveness and safety of Aurantii Fructus Immaturus flavonoid (AFIF) tablets compared to domperidone for treating functional dyspepsia (FD).
  • After 4 weeks of treatment, both AFIF and domperidone showed similar rates of symptom relief, but AFIF had a significantly higher rate of symptom disappearance 4 weeks after stopping treatment.
  • The AFIF group also experienced fewer adverse events, suggesting a better safety profile compared to domperidone.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to assess how Weichang'an pill (WCAP) affects functional dyspepsia (FD) in rats, focusing on brain-gut peptides and gut microbiota as potential treatment mechanisms.
  • Researchers created an FD rat model and divided the rats into different treatment groups, including those receiving WCAP and a control for comparison, then measured gastrointestinal motility and gut microbiota composition.
  • Results showed that WCAP improved FD symptoms by enhancing gastric emptying, regulating brain-gut peptide levels, and restoring gut microbiota balance, suggesting it could be an effective treatment for FD.
View Article and Find Full Text PDF

Brain drug delivery from the nasal olfactory region is enhanced using lauroylcholine chloride: An estimation using in vivo PET imaging.

Nucl Med Biol

December 2024

Molecular Imaging Laboratory, Division of Preeminent Bioimaging Research, Institute of Photonics Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-ku, Hamamatsu 431-3192, Japan. Electronic address:

Introduction: Intranasal (IN) administration, often referred to as nose-to-brain (N2B) drug delivery, is an attractive approach for delivering drugs to the central nervous system. However, the efficacy of this method is limited because of the small size of the nasal olfactory region, which limits the drug dosage. Using permeation enhancers could improve drug delivery from this region to the brain, though their effects are not fully understood.

View Article and Find Full Text PDF

Induced lactation in a transgender woman: case report.

Int Breastfeed J

September 2024

The Nippon Foundation Human Milk Bank, Tokyo, Japan.

Background: Breastfeeding offers significant health benefits, but its practice and success can vary. While research on induced lactation in cisgender women has been documented, there is limited research on lactation induction in transgender women.

Case Presentation: A 50-year-old transgender woman undergoing hormone therapy and living with a pregnant partner sought to co-feed using induced lactation.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!