Rats were screened in an alcohol-water free-choice paradigm and divided into low-ethanol preferring (1.5-2.5 g/kg/day), medium-ethanol-preferring (2.5-4.5 g/kg/day) and high-ethanol-preferring (4.5-6.0 g/kg/day) groups. In addition, a non-ethanol-exposed group was included. Each of these groups was again subdivided with half the animals in a group being food deprived for 16 hr, and the other half having ad lib access to food. All rats were then subjected to restraint in the supine position in a cold (4-6 degrees C) environment for 3 hr. Significant differences in ulcer incidence and severity (cumulative length of the ulcers expressed in millimeters) occurred, suggesting that higher intake of alcohol is associated with greater ulcer severity. This pattern occurred for both food-deprived and non-deprived animals.
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In insects and mammals, 3D genome topology has been linked to transcriptional states yet whether this link holds for other eukaryotes is unclear. Using both ligation proximity and fluorescence microscopy assays, we show that in , () genes dispersed across multiple chromosomes and under the control of Heat Shock Factor (Hsf1) rapidly reposition in cells exposed to acute ethanol stress and engage in concerted, Hsf1-dependent intergenic interactions. Accompanying 3D genome reconfiguration is equally rapid formation of Hsf1-containing condensates.
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bioRxiv
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In insects and mammals, 3D genome topology has been linked to transcriptional states yet whether this link holds for other eukaryotes is unclear. Using both ligation proximity and fluorescence microscopy assays, we show that in , () genes dispersed across multiple chromosomes and under the control of Heat Shock Factor (Hsf1) rapidly reposition in cells exposed to acute ethanol stress and engage in concerted, Hsf1-dependent intergenic interactions. Accompanying 3D genome reconfiguration is equally rapid formation of Hsf1-containing condensates.
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Front Bioeng Biotechnol
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State Key Laboratory of Biocatalysis and Enzyme Engineering, Environmental Microbial Technology Center of Hubei Province and School of Life Sciences, Hubei University, Wuhan, China.
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- The microorganism studied shows promise for producing bioethanol, but ethanol toxicity limits its growth and production.
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College of Enology, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, China; Ningxia Helan Mountain's East Foothill Wine Experiment and Demonstration Station of Northwest A&F University, Yongning, Ningxia 750104, China. Electronic address:
There has been a growing interest in developing co-inoculum of Oenococcus oeni and Saccharomyces cerevisiae/non-Saccharomyces for simultaneous malolactic fermentation (MLF) and alcoholic fermentation (AF) of wines. This study sought to elucidate the effects of two crucial factors (inoculation timing and paired yeast) on the fermentation performance and aroma production of Merlot wine. O.
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