A study has been made, using light and electron microscopy, of GMG cells in the labyrinthine placenta of the mouse. GMG cells were found lying within the lumina of the maternal blood spaces showed degenerative changes and GMG cells were usually found close to these degenerate trophoblast cells. Sometimes the GMG cells also showed degenerative changes. The observations suggest that an interaction may take place between GMG cells and layer 1 trophoblast cells and support the idea that the labyrinthine placenta is a site of functional significance to GMG cells.
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