Ultrastructure of the rat sensomotor and acoustic cortex has been studied at a separate and joined effect of noise and alcoholic intoxication during 7 and 35 days. Certain changes in vessels, neural and glial cells specific for separate effect of noise and alcohol have been revealed. Combined application of noise and alcohol results in a more profound disorders in the cerebral vessels, with predominance of changes specific for alcoholic intoxication. Simultaneous decrease of the ultrastructural changes, peculiar for the separate effect of noise is explained as a decreasing functional loading on the cortical cells resulted from blocking synapses with alcohol.

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