Thirty patients with mitral stenosis were examined according to the Bakulev-Damir classification during right heart catheterization at rest, with loading and during the rehabilitation period. The relationships found between the extent of the resistance at rest and the character of the degree of its changes at loading, reflecting the stenosis evolution, provide grounds for the differentiation of four stages, four substages resp., in its classification, namely: Second A substage with sinus rhythm, without included protective reaction of a. Pulmonalis periphery at rest, with markedly manifested peripheral vasodilation with loading. Second B substage with sinus rhythm, protective reaction of a. Pulmonalis periphery at rest included to a lesser degree, excluded loading, with a following manifested vasodilation. Second C substage with absolute arrhythmia, included to a lesser degree protective reaction of a. Pulmonalis periphery at rest, excluded with loading, with a following slighter vasodilation. Second D substage with sinus rhythm, included protective reaction at a. Pulmonalis periphery at rest, considerably intensified with loading. The extent and dynamics of the rest of the values studied are followed up in the separate stenosis substages aiming at their complete hemodynamic characterization. The pathogenetic mechanism of the pulmonary edema in the second stenosis stage is analyzed, not rarely conditioning the clinical pardox "minor stenosis of mitral valve with menacing pulmonary edemas".
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Cancers (Basel)
October 2024
University Hospital of Zurich, 8091 Zurich, Switzerland.
Background: Although data on patients treated with pembrolizumab are available from clinical trials and single-country real-world reports, to our knowledge no multi-country real-world studies have investigated the use of pembrolizumab as an adjuvant treatment for stage III melanoma.
Methods: We used the European Melanoma Registry (EUMelaReg), a disease entity-based registry specific for melanoma, to examine treatment and outcomes for adult patients with stage III melanoma with lymph node involvement who had complete resection and received adjuvant treatment with pembrolizumab. The primary objectives were to describe the demographic and clinical characteristics of the included patients as well as time on adjuvant pembrolizumab treatment (TOT), real-world recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) from adjuvant pembrolizumab initiation.
Arch Esp Urol
September 2024
Department of Urology, ASST Fatebenefratelli-Sacco Hospitals, 20157 Milan, Italy.
Background: The World Health Organization (WHO) classification system for bladder cancer (BC) advocates for the substaging of pT1 disease, which may improve the prediction of cancer recurrence and progression. This study aims to evaluate the application and prognostic significance of a micrometric substaging system, utilising a 1 mm cut-off depth of invasion in patients with pT1 BC.
Methods: We retrospectively reviewed all patients diagnosed with pT1 High-Grade Non-Muscle Invasive Bladder Cancer (NMIBC) at our institution.
Sleep
December 2024
School of Psychology, University of Surrey, Guildford, UK.
Study Objectives: Alpha and theta oscillations characterize the waking human electroencephalogram (EEG) and can be modulated by closed-loop auditory stimulation (CLAS). These oscillations also occur during rapid eye movement (REM) sleep, but their function here remains elusive. CLAS represents a promising tool to pinpoint how these brain oscillations contribute to brain function in humans.
View Article and Find Full Text PDFMethods Mol Biol
August 2024
State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Mammalian meiosis is a highly specialized cell division process, resulting in the production of genetically unique haploid cells. However, the molecular mechanisms governing meiosis remain largely unknown, primarily due to the difficulty in isolating pure sub-populations of spermatocytes. Definitive molecular, biochemical, and functional investigations of the meiosis process require the isolation of these individual homogeneous sub-populations of spermatocytes.
View Article and Find Full Text PDFEur J Surg Oncol
September 2024
Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Chengdu, Sichuan, China. Electronic address:
Background: In 2023, the International Federation of Gynecology and Obstetrics (FIGO) updated the endometrial cancer staging system (FIGO2023). Our study aimed to validate the prognostic value of FIGO2023 in patients with early-stage EC (Stage I and Stage II).
Methods: After screening eligible EC patients from the Surveillance, Epidemiology and End Results (SEER) database, Kaplan-Meier cancer-specific survival (CSS) curves were used to evaluate the prognosis of patients with different stages.
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