It has been demonstrated in experiments on puberal and infantile female rats that a single subcutaneous injection of clonidine (0.03 mg/kg) disturbed whereas in a dose of 1 mg/kg completely inhibited spontaneous or induced ovulation as well as sexual receptivity. When injected in a daily dose of 0.03 mg/kg to puberal rats for 8 days clonidine potentiated the total gonadotropic activity of the pituitaries. When injected in a daily dose of 0.5 mg/kg for 10 days the drug induced the disorders of the estrous cycle during diestrus.
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