Intracellular calcium transport in the myocardium has been studied in dogs with experimental informational neurosis. It has been shown that in such dogs, the Ca-accumulating ability of the sarcoplasmic reticulum and mitochondria was significantly reduced. At the same time the content of endogenous Ca2+ in the intracellular structures under consideration remained unchanged.
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Rev Gaucha Enferm
January 2025
Universidade Estadual de Feira de Santana, Programa de Pós-Graduação em Ciências Farmacêuticas, Feira de Santana, Bahia, Brasil.
Objective: To verify the effects of instructional therapeutic play on the behavior of children during the first attempt at peripheral intravenous catheterization.
Method: This is a quasi-experimental post hoc analysis with a non-equivalent control group, secondary to a randomized clinical trial. The convenience sample comprised 193 children, allocated for convenience into an intervention group (preparation for catheterization with a therapeutic play; n=101 children) and a control group (preparation with structured conversation supported by the use of a booklet; n=92 children).
Proc Natl Acad Sci U S A
January 2025
Wellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford OX1 3TA, United Kingdom.
Daily life for humans and other animals requires switching between periods of threat- and reward-oriented behavior. We investigated neural activity associated with spontaneous switching, in a naturalistic task, between foraging for rewards and seeking information about potential threats with 7T fMRI in healthy humans. Switching was driven by estimates of likelihood of threat and reward.
View Article and Find Full Text PDFArch Sex Behav
January 2025
School of Kinesiology and Health Science, 301F Stong College, York University, 4700 Keele St., Toronto, ON, Canada.
Critiques from queer theory have suggested that the legalization of same-sex marriage (SSM) predominantly benefits White, middle-class segments of the lesbian, gay, and bisexual (LGB) community. This study investigates the impact of the legalization of SSM on mental health among Black LGB individuals, focusing on those with lower incomes in the UK. Using a nationally representative panel sample and employing a quasi-experimental methodology, we analyzed changes in psychological distress and life dissatisfaction following the legalization of SSM.
View Article and Find Full Text PDFMethods Mol Biol
January 2025
Research and Innovation Centre, Fondazione E. Mach, Trento, Italy.
Liquid Chromatography-Mass Spectrometry (LC-MS) untargeted experiments require complex bioinformatic strategies to extract information from the experimental data. Here we discuss the "data preprocessing," the set of procedures performed on the raw data to produce a data matrix which will be the starting point for the subsequent statistical analysis. Data preprocessing is a crucial step on the path to knowledge extraction, which should be carefully controlled and optimized in order to maximize the output of any untargeted metabolomics investigation.
View Article and Find Full Text PDFAnn Surg Oncol
January 2025
Department of Surgery, Faculty of Medicine, Kindai University, Osaka-Sayama, Osaka, Japan.
Background: To improve the prognosis of clinically resectable type 4 or large type 3 gastric cancer (GC), we performed a phase I/II study of neoadjuvant-radiotherapy combined with S-1 plus cisplatin.
Patients And Methods: Phase I, with a standard 3 + 3 dose-escalation design, was performed to define the recommended phase II dose. Efficacy and safety were evaluated in phase II.
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