[The course of pain in patients with confirmed duodenal ulcer under therapy with cimetidine].

In an open multicenter trial 1047 patients with endoscopically or X-ray verified duodenal ulcer were treated with 400 mg Cimetidin (Tagamet) b.i.d. The analysis of subjective pain records demonstrates 69% of the patients to suffer from severe pain before start of treatment while 3% were pain-free. Two days after start of treatment a statistically significant reduction (p less than 0.01) of intensity of pain has been proven. Five days after onset of treatment 30% of the patients are pain-free, 33% show minor impairment of well-being, 25% report moderate pain and 12% show clinically relevant pain.