Several studies have shown that isolation-induced aggressive behavior in rodents may involve alterations in brain serotonin metabolism. The modified response, in isolated, aggressive mice, to several agents specific to serotonin receptors in the brain suggests an altered receptor availability for serotonin-like ligands. In the present study, isolated, aggressive mice showed a significant reduction in the number of serotonin binding sites in three major brain regions, and the effect of amphetamine sulfate varies according to the changes of receptors in differentially housed mice.
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