The experiments were carried out on rats of Wistar (W) and Krushinsky-Molodkina (KM) lines, differing in the level of task performance in conditions of multiple choice of food sources in a 12ray radial symmetrical maze. It is shown that in the radial maze, the rats of both lines use a number of behavioural tactics. To determine the influence of changes of environmental spatial characteristics while preserving the main experimental strategy--never revisit the places of reinforcement,--on the peculiarities of tactics manifestations maze modifications were elaborated. Besides the environmental procedure was changed. Under all conditions the rats of W line solved the task. According to the situation, they either preserved former tactics or developed some new ones. The rats of KM line could not solve the task in changed conditions. In most sessions, appearance or absence of given tactics was not adequate to new conditions. The presence of the necessary tactics not always facilitated the task solving. Thus, for the realization of adequate reactions, the presence of necessary tactics is not sufficient: their "tuning" is needed depending on situation. The possibility is supposed of genetic determination of rats ability to some tactics. However, it is emphasized, that tactics are not strongly fixed, as their realization depends on environmental conditions.
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Anesth Analg
January 2025
From the Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Camperdown, New South Wales, Australia.
Tapering opioids is an effective strategy to reduce the risks associated with long-term opioid therapy. However, patients' experience with tapering can influence the success of this treatment. Understanding patients' experiences with opioid tapering will allow for patient-centered approaches to be adopted to tailor interventions to achieve safe and successful taper outcomes.
View Article and Find Full Text PDFPlast Reconstr Surg
February 2025
From the Section of Plastic Surgery, Department of Surgery, University of Michigan Medical School.
Front Psychol
January 2025
Department of Primary Education, National and Kapodistrian University of Athens, Athens, Greece.
Introduction: Teacher burnout is a serious problem that requires quick attention and management since it not only compromises educational quality but also strains schools' financial resources.
Research Objective: The purpose of the present study was to profile burnout indicators for teachers in the Kingdom of Saudi Arabia. A secondary goal was to evaluate the consistency of burnout profiles between elementary and secondary school teachers.
Pharm Nanotechnol
January 2025
Department of General Medicine, SRMC & RI, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai -600116, Tamil Nadu, India.
Aim: This study aimed to develop and evaluate lornoxicam (LXM) and thiocolchicoside (TCS) transferosomal transdermal patches.
Background: Oral administration of LXM and TCS can lead to gastric irritation, necessitating alternative delivery methods for pain and inflammation relief. Incorporating LXM & TCS into transferosomes within a transdermal patch offers a potential solution.
Sports Med Open
January 2025
Mechanical Engineering Department, Texas Tech University, Lubbock, TX, USA.
Background: Drafting for drag reduction is a tactic commonly employed by elite athletes of various sports. The strategy has been adopted by Kenyan runner Eliud Kipchoge on numerous marathon events in the past, including the 2018 and 2022 editions of the Berlin marathon (where Kipchoge set two official world records), as well as in two special attempts to break the 2 h mark for the distance, the Nike Breaking2 (2017) and the INEOS 1:59 Challenge (2019), where Kipchoge used an improved drafting formation to finish in 1:59:40, although that is not recognized as an official record.
Results: In this study, the drag of a realistic model of a male runner is calculated by computational fluid dynamics for a range of velocities.
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