The effect of the polyamine spermine previously shown to suppress erythropoiesis in vitro was investigated in a long term animal experiment. Continuous application of spermine by intraperitoneally implanted microperfusion pumps caused a mild hypoproliferative microcytic anemia in normal rats. Furthermore, in 12 patients with advanced renal insufficiency spermine was shown to be markedly elevated. This, together with the results obtained in animal experiments, suggests that hypersperminemia is the reason for the impaired erythropoiesis in anemic uremic patients.
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