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Development of optimized standardized extracts of Echinodorus macrophyllus for arthritis management.
J Ethnopharmacol
February 2025
Departament of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, campus Pampulha, Avenida Antônio Carlos 6627, 31.270-901, Belo Horizonte, MG, Brazil. Electronic address:
Ethnopharmacological Relevance: Echinodorus macrophyllus is a medicinal plant traditionally used in Brazil to treat rheumatic diseases. It is listed as a priority species for the development of herbal preparations for the Brazilian Unified Health System (SUS). Previous studies have demonstrated the anti-inflammatory and antiedematogenic properties of extracts and fractions from this species, but these preparations were neither standardized nor optimized for anti-arthritis effects.
View Article and Find Full Text PDFA novel aptasensor integrating the DNA rolling nanomachine and Tb/COF/KB as dual signal amplifiers for kanamycin detection in foods.
Food Chem
February 2025
Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China. Electronic address:
A novel aptasensor for the detection of kanamycin (KNM) was developed based on dual signal amplification through nanomaterials and DNA rolling machines. Firstly, a composite consisting of the covalent organic framework (COF), ketjen black (KB) and toluidine blue (Tb), was synthesized for signal generation. Tb molecules were loaded into the composite and combined with AuNPs to serve as tracer label.
View Article and Find Full Text PDFAmitraz mechanisms of cytotoxicity in a characterized SH-SY5Y cells spheroid model.
Toxicology
December 2024
Research Group in Alternative Methods for Determining Toxics Effects and Risk Assessment of Contaminants and Mixtures (RiskTox). Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy and Food Science, University of Valencia, Av. Vicent Andrés Estellés s/n, Burjassot, Valencia 46100, Spain.
Article Synopsis
- * This study focused on SH-SY5Y cell spheroids to examine the cytotoxic effects of amitraz (AMZ), an acaricide found in honey at illegal levels, and found significant cell response data after exposure.
- * Results showed that while AMZ did not cause inflammation, it led to late apoptosis and changes in specific protein expression, highlighting spheroids as valuable tools for studying the toxicity and mechanisms of compounds like AMZ.
Prevalence of elevated sNFL in a real-world setting: Results on 908 patients with different multiple sclerosis types and treatment conditions.
Mult Scler Relat Disord
August 2024
NICO - Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Italy.
Background: In the field of research for new validated surrogate biomarkers of treatment efficacy, disease activity and progression in Multiple Sclerosis (MS), serum neurofilament light-chain (sNFL) are actually the best candidate for MS patient monitoring. However, before they can be implemented in clinical practice, their usefulness as additional red flag routine measure must be demonstrated. To tackle the problem, this real-life cross-sectional study at the Regional Referring Center for Multiple Sclerosis (CRESM) aims to characterize sNFL levels and prevalence of elevated sNFL, according to our age-dependent cut-off values, in a large group of patients with different types of MS and treatment conditions.
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