The article discusses how and why drug responses are altered in elderly patients. It describes how the mutation of body composition and decay of physiological functions in the aged alters the pharmacokinetic parameters and consequently the drug responses. It also provides guidelines on which to base estimates of an accurate drug schedule.
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Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that is primarily known for causing severe joint and muscle symptoms, but its pathological effects have extended beyond these tissues. In this study, we conducted a comprehensive proteomic analysis across various organs in rodent and nonhuman primate models to investigate CHIKV's impact on organs beyond joints and muscles and to identify key host factors involved in its pathogenesis. Our findings reveal significant species-specific similarities and differences in immune responses and metabolic regulation, with proteins like Interferon-Stimulated Gene 15 (ISG15) and Retinoic Acid-Inducible Gene I (RIG-I) playing crucial roles in the anti-CHIKV defense.
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Front Med (Lausanne)
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Rheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, Italy.
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Systems Pharmacology and Translational Therapeutics Laboratory, The Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University, Chieti, Italy.
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Front Chem
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Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
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