AI Article Synopsis
- An increase in erythroblastic islands with central macrophages was noted in the bone marrow of six rheumatoid arthritis patients experiencing anemia.
- This increase suggests a link to ineffective erythropoiesis, which is the process of producing red blood cells that aren't functioning properly.
- The findings indicate that this morphological change could be a response to the heightened ineffective erythropoiesis observed in RA patients who have anemia.
Article Abstract
An increase of erythroblastic islands with recognizable central macrophages was observed in bone marrow of six rheumatoid arthritis (RA) patients suffering from anaemia. Since erythroblastic islands are more prominent in anaemic conditions associated with ineffective erythropoiesis, it is possible that this morphological finding might be an expression of the increased ineffective erythropoiesis observed in RA patients with anaemia.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Transsulfuration pathway activation attenuates oxidative stress and ferroptosis in sickle primary erythroblasts and transgenic mice.
Commun Biol
January 2025
Georgia Cancer Center, Augusta University, Augusta, GA, 30912, USA.
The transsulfuration (TSS) pathway is an alternative source of cysteine for glutathione synthesis. Little of the TSS pathway in antioxidant capacity in sickle cell disease (SCD) is known. Here, we evaluate the effects of TSS pathway activation through cystathionine beta-synthase (CBS) to attenuate reactive oxygen species (ROS) and ferroptosis stresses in SCD.
View Article and Find Full Text PDFComparative in situ characterization of erythroid cells found throughout the developing tongue tissue, circulation, and liver of fetal mice.
Ann Anat
February 2025
Department of Anatomy, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan. Electronic address:
Background: Erythroid cells contribute to embryonic organ development and adult tissue repair supplying oxygen to tissues. During mouse development, the primitive erythroid cells produced in the extraembryonic blood islands of the yolk sac begin to circulate as immature and nucleated erythroblasts with the onset of cardiac contractions around embryonic day 9.5 (E9.
View Article and Find Full Text PDFThe Impact of Sodium Selenite and Seleno-L-Methionine on Stress Erythropoiesis in a Murine Model of Hemolytic Anemia.
J Nutr
December 2024
Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States. Electronic address:
Background: Selenium (Se) is an essential trace element that exerts most biological activities through selenoproteins. Dietary selenium is a key regulator of red cell homeostasis and stress erythropoiesis. However, it is unknown whether the form and increasing doses of Se supplementation in the diet impact stress erythropoiesis under anemic conditions.
View Article and Find Full Text PDFGLTSCR1, a protein encoded by the Bicra gene, is a defining subunit of the SWI/SNF (also called mammalian BAF) chromatin remodeling subcomplex called GBAF/ncBAF. To determine the role of GLTSCR1 during mouse development, we generated a Bicra germline knockout mouse using CRISPR/Cas9. Mice with homozygous loss of Bicra were born at Mendelian ratios but were small, pale and died within 24 hours after birth.
View Article and Find Full Text PDF[Research progress on erythroblastic islands in erythroid development and related diseases].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
October 2024
Department of Medical Genetics and Developmental Biology, Basic Medical Science Academy, Air Force Medical University, Xi'an 710032, China. *Corresponding author, E-mail:
Erythroblastic islands (EBIs) are specialized structures that are formed by a central macrophage surrounded by maturating erythroblasts. The central macrophage mediates EBI formation and plays a crucial role in the proliferation, differentiation, enucleation, and maturation of erythroblasts. In stress erythropoiesis, the expression levels of several adhesion molecules mediating EBI formation become abnormal, leading to various erythroid diseases.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!