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Optimal intervention timing for craniocerebral radiotherapy in EGFR mutant lung adenocarcinoma patients with brain metastases.
BMC Cancer
December 2024
Department of Radiation Oncology, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Cancer Hospital and Institute, Jinan City, 250117, China.
Background: Intracranial radiation in combination with EGFR targeted therapy demonstrated signals of superiority to EGFR targeted therapy alone based on several observational studies. The timing based on specific criteria is not clear, and we evaluated the efficacy of intervention timing of craniocerebral radiotherapy (RT) combined with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) on prognosis of patients with EGFR mutant lung adenocarcinoma complicated with brain metastasis.
Methods: In total, 603 patients with advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations were enrolled in this retrospective study between March 2008-September 2023.
The neurodevelopmental regulatory role and clinical value of hsa-circ-CORO1C-hsa-miR-708-3p-JARID2 + LNPEP axis in early-onset schizophrenia.
Schizophrenia (Heidelb)
December 2024
Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, China.
Genes discovered by previous epigenetic studies of schizophrenia have focused solely on diagnostics or pathology, potentially leading to a disconnection between them. Using these molecules to identify the disease is considered insufficient. MicroRNAs (miRNAs) binding to messenger RNAs (mRNAs) can lead to mRNA degradation, while circular RNAs (circRNAs), by binding to miRNAs as sponge, can reduce the inhibitory effect of miRNAs on mRNAs.
View Article and Find Full Text PDF[Modern acupuncture anesthesia and its clinical practice].
Zhen Ci Yan Jiu
December 2024
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Acupuncture anesthesia is an innovative anesthesia technique which combines acupuncture therapy of traditional Chinese medicine with western anesthesia and surgery. Modern acupuncture anesthesia technology involves comprehensive preoperative evaluation and application, intraoperative assistance in anesthesia, and enhanced recovery after surgery, forming a set of perioperative management models with Chinese characteristics. In the present paper, we comprehensively summarized the application scenarios (including craniocerebral operations, neck surgery, cardiac and thoracic surgery, abdominal operation, obstetrical and gynecological operations, anorectal operation, and orthopedic operation) and values (such as analgesia, reduction in nausea and vomiting, accelerating recovery of gastrointestinal function, regulating immune function, etc.
View Article and Find Full Text PDFEfficacy and safety of combining anti-angiogenic therapy, radiotherapy, and PD-1 inhibitors in patients with driver gene-negative non-small cell lung cancer brain metastases: a retrospective study.
BMC Cancer
December 2024
Department of Radiation Oncology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Article Synopsis
- The study investigates the effectiveness and safety of anti-angiogenic combination therapy in driver gene-negative non-small cell lung cancer (NSCLC) patients with brain metastases, comparing a group receiving this therapy (AT) to one receiving standard treatment (NAT).
- Results show that the AT group had higher initial objective response rates (iORR) and longer progression-free survival rates compared to the NAT group, indicating better clinical efficacy of the combined therapy.
- Despite the longer progression-free intervals, the overall survival rate (OS) did not significantly improve with anti-angiogenic therapy, and while the AT group experienced more hypertension, there was no significant increase in radiation-induced brain necrosis.
Factors associated with decisions to refer possible abusive head trauma to a hospital-based child protection team in Aotearoa New Zealand.
Child Abuse Negl
December 2024
ReedNZ Ltd, Rotorua, New Zealand. Electronic address:
Article Synopsis
- Aotearoa New Zealand has a significant rate of abusive head trauma (AHT) among children, prompting the need for referrals to a specialized child protection team (CPT), but no prior research has explored what influences these referral decisions.
- The study analyzed data from children under 5 years old with head injuries from 2010 to 2019 to identify factors affecting the likelihood of being referred to the CPT.
- Results showed that various factors, like age under one, inconsistent injury histories, and social concerns, significantly influenced referral decisions, aligning with existing literature and resulting in a high model accuracy (AUROC of 0.95).
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