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Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis.
Cell Host Microbe
July 2020
4(th) Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62 Athens, Greece. Electronic address:
Dysregulation of inflammation is hypothesized to play a crucial role in the severe complications of COVID-19, with the IL-1/IL-6 pathway being central. Here, we report on the treatment of eight severe COVID-19 pneumonia patients-seven hospitalized in intensive care units (ICUs) in Greece and one non-ICU patient in the Netherlands-with the interleukin-1 receptor antagonist Anakinra. All patients scored positive for the hemophagocytosis score (HScore) and were diagnosed with secondary hemophagocytic lymphohistocytosis (sHLH) characterized by pancytopenia, hyper-coagulation, acute kidney injury, and hepatobiliary dysfunction.
View Article and Find Full Text PDFConsensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia.
Blood
February 2017
Institute of Hematology, Department of Medicine, University and Hospital of Perugia, Perugia, Italy.
Hairy cell leukemia is an uncommon hematologic malignancy characterized by pancytopenia and marked susceptibility to infection. Tremendous progress in the management of patients with this disease has resulted in high response rates and improved survival, yet relapse and an appropriate approach to re-treatment present continuing areas for research. The disease and its effective treatment are associated with immunosuppression.
View Article and Find Full Text PDFUnrestricted somatic stem cells: interaction with CD34+ cells in vitro and in vivo, expression of homing genes and exclusion of tumorigenic potential.
Cytotherapy
March 2011
Molecular Oncology of Solid Tumors, DKFZ (German Cancer Research Center), Heidelberg, Germany.
Background Aims: Transplantation of allogeneic hematopoietic stem cells (HSC) within the framework of hematologic oncology or inherited diseases may be associated with complications such as engraftment failure and long-term pancytopenia. HSC engraftment can be improved, for example by co-transplantation with mesenchymal stem cells (MSC). Recently, a new multipotent MSC line from umbilical cord blood, unrestricted somatic stem cells (USSC), has been described.
View Article and Find Full Text PDFGenotoxicity of intermittent co-exposure to benzene and toluene in male CD-1 mice.
Chem Biol Interact
June 2008
The Hamner Institutes for Health Sciences, 6 Davis Drive, PO Box 12137, Research Triangle Park, NC 27709-2137, USA.
Benzene is an important industrial chemical. At certain levels, benzene has been found to produce aplastic anemia, pancytopenia, myeloblastic anemia and genotoxic effects in humans. Metabolism by cytochrome P450 monooxygenases and myeloperoxidase to hydroquinone, phenol, and other metabolites contributes to benzene toxicity.
View Article and Find Full Text PDF[Hodgkin's disease with bone marrow involvement. The role of positron tomography].
Presse Med
February 2005
Service d'hématologie clinique, Hôpital d'Instruction des Armées Percy, 101 avenue Henri Barbusse, 92141 Clamart, France.
Introduction: Hodgkin's disease with initially predominant bone marrow involvement is observed in 1% of cases.
Observation: A case of Hodgkin's disease with massive bone marrow invasion, manifested by pancytopenia in the context of fever and alteration in general status of health, with little or non superficial peripheral lymph nodes. The bone marrow biopsy revealed extensive myelofibrosis with rare Reed-Sternberg cells.
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