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Choroidal thickness as predictor of subclinical carotid atherosclerosis in adults with type 1 diabetes.
Sci Rep
March 2025
Department of Endocrinology & Nutrition, Hospital de la Santa Creu i Sant Pau, Sant Quintí, 89, 08041, Barcelona, Spain.
Patients with Type 1 Diabetes (T1DM) have a higher risk of cardiovascular disease. This study used carotid ultrasound to identify subclinical carotid plaques and Optical Coherence Tomography (OCT) to evaluate ophthalmological markers as predictors of carotid plaque presence in 242 adults with T1DM, employing machine learning models for early risk assessment. Individuals with carotid plaques (N = 67) did not show significant differences in retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) and inner plexiform layer (IPL) complex compared to those without (N = 175).
View Article and Find Full Text PDFAssociation of Retinal Arterial Narrowing With New-Onset Carotid Plaque: A Chinese Community-Based Nested Case-Control Cohort Study.
J Clin Hypertens (Greenwich)
March 2025
Department of Cardiology, Peking University First Hospital, Beijing, Beijing, China.
To investigate whether retinal arterial narrowing is associated with incident carotid plaque in the general population. Individuals without carotid plaque in 2014 who developed new-onset carotid plaque in 2018 were selected as cases (n = 156) for the atherosclerosis group and matched for age and sex in a ratio of 1:1 for the control group. The effects of the baseline central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE), and arteriovenous ratio (AVR) on the risk of new-onset carotid plaque were evaluated in multivariable conditional logistic regression models.
View Article and Find Full Text PDFProgress in the treatment of vascular complications in type 2 diabetes by finerenone in combination with RAS inhibitors/SGLT-2i.
J Diabetes Complications
February 2025
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China; Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan 030032, China; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:
Background: Currently, the prevalence of diabetes is rising. Patients with diabetes often face high risks of kidney disease, cardiovascular disease, and retinal disease. Cardiovascular complications are the primary cause of morbidity and mortality in patients with type 2 diabetes mellitus.
View Article and Find Full Text PDFRetinal microstructure and microvasculature in association with brain amyloid burden.
Brain Commun
February 2025
National Institute of Neurological Disorders and Stroke Intramural Research Program, National Institutes of Health, Bethesda, MD 20814, USA.
Cortical amyloid burden is associated with neuronal and vascular abnormalities. The retina shares significant structural and physiological similarities with the brain. This study assessed the association of retinal microstructural and microvascular signs with cortical amyloid burden in the prospective Atherosclerosis Risk in Communities-Positron Emission Tomography study.
View Article and Find Full Text PDFSex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging.
Nat Aging
February 2025
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
Aging leads to progressive decline in organ and tissue integrity and function, partly due to loss of proteostasis and autophagy malfunctioning. A decrease with age in chaperone-mediated autophagy (CMA), a selective type of lysosomal degradation, has been reported in various organs and cells from rodents and humans. Disruption of CMA recapitulates features of aging, whereas activating CMA in mice protects against age-related diseases such as Alzheimer's, retinal degeneration and/or atherosclerosis.
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