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Prokinetic Activity of Mulberry Fruit, L.
Nutrients
April 2023
Biopharmaceutical Engineering Major, Division of Applied Bioengineering, College of Engineering, Dong-Eui University, Busan 47340, Republic of Korea.
The fruit of L. (MAF) has been consumed as a food worldwide. MAF has also been widely used in traditional medicine for thousands of years in East Asia, and its diverse bioactivities have been reported in numerous publications.
View Article and Find Full Text PDFCharacterization of dual layered pellets for sustained release of poorly water-soluble drug.
Chem Pharm Bull (Tokyo)
July 2007
National Research Laboratory for Bioavailability Control, College of Pharmacy, Kangwon National University, Chuncheon, Korea.
The aim of this study was to develop pellet formulations that could be used to improve the dissolution and bioavailability of a poorly water-soluble model drug, cisapride. Six different types of pellets were prepared by coating sugar spheres in a fluidized bed coater. When the sugar spheres were single layered containing cisapride and solubilizer such as polysorbate 80, the resulting pellets provided an instant release of cisapride in the simulated gastric fluid.
View Article and Find Full Text PDFPharmacological characterization of 5-hydroxytryptamine-induced contraction in the chicken gastrointestinal tract.
Auton Autacoid Pharmacol
April 2006
Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.
5-Hydroxytryptamine (5-HT) receptor subtypes involved in 5-HT-induced contraction of the chicken gastrointestinal tract were characterized pharmacologically using subtype-selective agonists and antagonists. The proventriculus (area of stomach adjacent to the oesophagus) and ileum are examined. 5-HT applied cumulatively caused sustained contraction of the proventriculus that was not decreased by tetrodotoxin, atropine or l-nitro-arginine methylester (l-NAME).
View Article and Find Full Text PDFRespiratory development in preterm infants.
J Perinatol
October 2004
School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7460, USA.
Objective: This study examined the development of respiration during the preterm and early post-term periods and the effects of other biological and environmental variables, including sleep state, on this development.
Study Design: Weekly 2-hour sleep observations and respiration recordings were obtained on 134 preterm infants from the time they were no longer critical until hospital discharge; a follow-up observation was conducted 1 to 3 months later.
Results: All respiratory variables, except length of respiratory pauses in quiet sleep, decreased although the rate of this decrease slowed after term for four variables.
Nizatidine and cisapride increase salivary secretion in rats.
Dig Dis Sci
March 2004
Department of Gastroenterology and Hepatology, Shimane University, Shimane, Japan.
Saliva is a neurally induced solution with buffering capacity against acidic solutions. Salivation therefore plays an important role in defending the esophageal mucosa against refluxed gastric acid and is evoked by cholinergic stimulation. Both nizatidine and cisapride are reported to increase acetylcholine concentrations in the postganglionic cholinergic synapses.
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