Prevention of neonatal mortality linked to prematurity may be achieved by treating preterm labor, thus allowing fetal lungs to spontaneously develop, or by administering drugs able to enhance pulmonary maturation. The methylxantine derivative aminophylline has been reported to reduce uterine contractility and increase the concentrations of saturated phosphatidylcholine in fetal lungs. Its effectiveness in treating preterm labor and preventing respiratory distress syndrome (RDS) has been evaluated in comparison to the widely used drug ritodrine. In 39 pregnant women with preterm labor the efficacy of aminophylline and ritodrine in delaying the delivery seemed similar. However, while two of the babies born from ritodrine treated mothers died because of RDS, all babies born from aminophylline-treated mothers survived. These data might then confirm the effectiveness of aminophylline treatment to prevent RDS.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Expression of the IGF‑1Ea isoform in human placentas from third trimester normal and idiopathic intrauterine growth restriction singleton pregnancies: Correlations with clinical and histopathological parameters.
Mol Med Rep
March 2025
Department of Pathology, Aretaieion University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Intrauterine growth restriction (IUGR) is the second most common obstetric complication after preterm labor. Appropriate trophoblast differentiation and placental structure, growth and function are key for the maintenance of pregnancy and normal fetal growth, development and survival. Extravillous trophoblast cell proliferation, migration and invasion are regulated by molecules produced by the fetomaternal interface, including autocrine factors produced by the trophoblast, such as insulin‑like growth factor (IGF)‑1.
View Article and Find Full Text PDFRelationship Between Maternal Serum Amyloid A Levels and Neonatal Outcomes in Preterm Births.
Cureus
December 2024
Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, ROU.
This study investigated the relationship between maternal serum amyloid A (SAA) levels, a biomarker of systemic inflammation, and specific neonatal outcomes in preterm birth (PTB). The study included 66 consecutive pregnant women hospitalized for spontaneous preterm delivery (ranging from 28 to 36 gestational weeks), at the Timisoara Municipal Hospital. The study measured mSAA levels to assess their potential as predictors of fetal outcomes (respiratory distress syndrome [RDS]), as well as their association with APGAR score, neonatal leukocyte count, and C-reactive protein (CRP) levels as indicators of neonatal status and response.
View Article and Find Full Text PDFBirth Outcomes of Infants Born to Mothers with Alopecia Areata: A Nationwide Population-based Study in Korea.
Acta Derm Venereol
January 2025
Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea.
Data on pregnancy outcomes in patients with alopecia areata (AA) are limited. The aim of this study is to determine the association between maternal AA and risk of adverse birth outcomes in children. A retrospective cohort study was conducted on 45,328 children born to mothers with AA and 4,703,253 controls born to mothers without AA using the Korean National Health Insurance Claims database from 2002 to 2016.
View Article and Find Full Text PDFCervical length of preoperative cervical cerclage prognostic impacted the effect of cervical insufficiency.
BMC Pregnancy Childbirth
January 2025
Department of Gynecology, Jiangnan University Medical Center, 68 Zhongshan Road, Liangxi Strict, Wuxi, Jiangsu, 214002, China.
Background: This study aimed to analyze the impact of preoperative cervical length before cervical cerclage on the extension of gestational days in patients with various diagnostic types of cervical insufficiency, including obstetric history-based diagnosis, ultrasound-based diagnosis, and physical examination-based diagnosis.
Methods: 168 patients were segregated into four categories based on cervical length: 0-0.4 cm, 0.
Partner conflict during their index pregnancy and its correlates among a cohort of six weeks postpartum women in Ethiopia.
Sci Rep
January 2025
Metages Yohannes Health Research Consultancy, Addis Ababa, Ethiopia.
Current intimate partner violence (IPV) during pregnancy was found to be associated with adverse health outcomes including pregnancy loss, preterm labor, pregnancy complications, hypertension, delivering low birth weight baby, physical injuries and stress. IPV in Ethiopia is considerably high. This study aimed at determining the prevalence of the IPV during the index pregnancy as measured at six weeks postpartum among women in their extended six weeks postpartum period and identify its correlates.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!