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Divergent paths of mammary gland involution: unveiling the cellular dynamics in abruptly and gradually involuted mouse models.
Breast Cancer Res
January 2025
Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Background: Epidemiological studies associate an increase in breast cancer risk, particularly triple-negative breast cancer (TNBC), with lack of breastfeeding. This is more prevalent in African American women, with significantly lower rate of breastfeeding compared to Caucasian women. Prolonged breastfeeding leads to gradual involution (GI), whereas short-term or lack of breastfeeding leads to abrupt involution (AI) of the breast.
View Article and Find Full Text PDFCellular distribution of some intermediate filaments in the rat mammary gland during pregnancy, lactation and involution.
Pol J Vet Sci
December 2024
Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Dicle, 21280 Diyarbakır, Turkey.
Intermediate filaments (IFs) play a major role in determining and maintaining cell shape and anchoring intracellular organelles in place, in the tissues and organs of several species, starting from the early stages of development. This study was aimed at the immunohistochemical investigation of the presence, cellular localization and temporal distribution of the intermediate filaments keratin 8 (CK8), keratin 18 (CK18), keratin 19 (CK19), vimentin, desmin and laminin, all of which contribute to the formation of the cytoskeleton in the rat mammary gland during pregnancy, lactation and involution. On days 7, 14 and 21 of pregnancy (pregnancy period), on day 7 post-delivery (lactation period) and on day 7 post-weaning (involution period), under ketamine hydrochloride (Ketalar-Pfizer) (90 mg/kg) anesthesia, two mammary glands were fully excised from the abdominal region.
View Article and Find Full Text PDFAssociation Between Breastfeeding Intensity and Mammary Gland Involution Markers in Early Postpartum Among Women from Low-Income Households.
Breastfeed Med
December 2024
Department of Nutrition, School of Health and Human Sciences, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.
The aim was to examine the associations between breastfeeding intensity and changes in concentrations of mammary gland involution markers (protein and lactose) among mothers participating in federal food assistance programs. Pregnant women in their third trimester who planned to breastfeed were recruited from local prenatal clinics ( = 25). After delivery, six weekly home visits were conducted to collect human milk samples and 24-hour infant feeding recalls.
View Article and Find Full Text PDFThe Untapped Opportunities of Addressing Lifecourse Growth in Mammographic Breast Density and Breast Cancer Prevention in Non-Hispanic Black Women.
Cancer Epidemiol Biomarkers Prev
December 2024
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
This commentary discusses the importance of adiposity and lifecourse growth with mammographic breast density (MBD) in non-Hispanic Black (NHB) women. Although high MBD is a well-established risk factor for breast cancer, the determinants of MBD in NHB women remain understudied. Although adiposity at the time of mammography is most strongly associated with MBD, adiposity as early as ages 10 and 18 years is also independently associated with MBD.
View Article and Find Full Text PDFArticle Synopsis
- Research shows that mammary gland aging can happen in cycles influenced by maternal ancestry, rather than just gradually over time.
- In these cycles, mouse mammary glands at 11 and 19 months show similarities related to cancer, while younger glands (3 and 14 months) do not, potentially explaining why breast cancer peaks around these ages.
- The study suggests that if harmful mutations in cells are avoided during the more vulnerable aging phases, rejuvenation might help delay cancer and could lead to longer lifespans in mice.
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