Tests were conducted on 90 smokers and a control group of 20 non-smokers using not only simple spirometry but also pneumotachography and the forced oscillation technique, including flow- and resistance-volume graphs. FEV1 was proved to be a sensitive screening test for early recognition of disfunction in the region of the small airways. 39,5% of the younger light smokers already showed signs of impairment to the breathing mechanics indicating exobronchial obstruction. The heavy, mostly older, smokers frequently showed complex disfunction, and in 55,3% the oscillatory resistance revealed quantifiable endobronchial obstruction. The oscillatory flow-resistance-increase-volume (as a percentage of vital capacity) proved the most sensitive small-airways-test during middle age, permitting significant distinction of smokers from non-smokers up to the age of 55.

Download full-text PDF

Source

Publication Analysis

Top Keywords

proved sensitive
8
[value spirometric
4
spirometric pneumotachographic
4
pneumotachographic oscilloresistometric
4
oscilloresistometric studies
4
studies functional
4
functional diagnosis
4
diagnosis obstructive
4
obstructive respiratory
4
respiratory tract
4

Similar Publications

In this paper, we designed and synthesized a novel based on quinoline modification half-salamo-type Zn(II) complex([Zn(L)(μ-OCH)]·(ClO)), namely ZP. The structure of ZP was determined by X-ray single-crystal diffraction, in which the Zn(II) ions displayed in two different coordination modes, ultimately forming a highly symmetric heptanuclear structure. The Zn(II) complex probe modified by quinoline luminescent group has excellent luminescence properties and selectively recognizes Fe in aqueous solution.

View Article and Find Full Text PDF

Background: Early identification of Developmental Coordination Disorder (DCD) in children is fundamental to provide the best chance of improving their outcomes. The Little Developmental Coordination Disorder Questionnaire (LDCDQ) is a screening tool to identify preschool children who may warrant a diagnosis of DCD.

Aims: This study conducted a transcultural translation and adaptation of the Italian version of the Little Developmental Coordination Disorder Questionnaire (LDCDQ-IT) and evaluated the psychometric properties of the tool, establishing also the optimal cut-off scores.

View Article and Find Full Text PDF

The incidence of acute myeloid leukemia (AML) is increasing annually, and timely diagnostic and treatments can substantially improve patient survival rates. AML typing traditionally relies on manual microscopy for classifying and counting myeloid cells, which is time-consuming, laborious, and subjective. Therefore, developing a reliable automated model for myeloid cell classification is imperative.

View Article and Find Full Text PDF

Development of a CRISPR-Cas12a based assay for the detection of swine enteric coronaviruses in pig herds in China.

Adv Biotechnol (Singap)

February 2024

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.

Porcine epidemic diarrhea virus (PEDV), Transmissible gastroenteritis virus (TGEV), Porcine deltacoronavirus (PDCoV) and Swine acute diarrhea syndrome coronavirus (SADS-CoV) rank among the most frequently encountered swine enteric coronaviruses (SECoVs), leading to substantial economic losses to the swine industry. The availability of a rapid and highly sensitive detection method proves beneficial for the monitoring and surveillance of SECoVs. Based on the N genes of four distinct SECoVs, a novel detection method was developed in this study by combining recombinant enzyme polymerase isothermal amplification (RPA) with clustered regularly interspaced short palindromic repeats (CRISPR)-associated proteins (Cas) 12a.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!