In rats with experimental cardiomyopathy the content of liver glycogen was considerably higher than in controls and the biogenic amines had no activating effect on glycogen phosphorolysis. The activity of monoamine oxidase was lower in experimental animals than in controls. After injections of monoamine oxidase inhibitors to normal rats no activation of phosphorolysis by biogenic amines was observed.
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Evidence for direct dopaminergic connections between substantia nigra pars compacta and thalamus in young healthy humans.
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The substantia nigra pars compacta (SNc), one of the main dopaminergic nuclei of the brain, exerts a regulatory function on the basal ganglia circuitry via the nigro-striatal pathway but its possible dopaminergic innervation of the thalamus has been only investigated in non-human primates. The impossibility of tract-tracing studies in humans has boosted advanced MRI techniques and multi-shell high-angular resolution diffusion MRI (MS-HARDI) has promised to shed more light on the structural connectivity of subcortical structures. Here, we estimated the possible dopaminergic innervation of the human thalamus via an MS-HARDI tractography of the SNc in healthy human young adults.
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