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A two-dimensional fluorescence and chemiluminescence orthogonal probe for discriminating and quantifying similar proteins.
Chem Sci
January 2025
Key Laboratory for Advanced Materials, Institute of Fine Chemicals, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, Center of Photosensitive Chemicals Engineering, East China University of Science and Technology Shanghai 200237 China
Given that proteins with minor variations in amino acid sequences cause distinct functional outcomes, identifying and quantifying similar proteins is crucial, but remains a long-standing challenge. Herein, we present a two-dimensional orthogonal fluorescence and chemiluminescence design strategy for the probe DCM-SA, which is sequentially activated by albumin-mediated hydrolysis, exhibiting light-up fluorescence and photo-induced cycloaddition generating chemiluminescence, enabling orthogonal signal amplification for discrimination of subtle differences between similar proteins. By orthogonalizing these dual-mode signals, a two-dimensional work curve of fluorescence and chemiluminescence is established to distinguish and quantify similar proteins HSA and BSA.
View Article and Find Full Text PDFEthics of Procuring and Using Organs or Tissue from Infants and Newborns for Transplantation, Research, or Commercial Purposes: Protocol for a Bioethics Scoping Review.
Wellcome Open Res
December 2024
National University of Singapore, Singapore, Singapore.
Unlabelled: Since the inception of transplantation, it has been crucial to ensure that organ or tissue donations are made with valid informed consent to avoid concerns about coercion or exploitation. This issue is particularly challenging when it comes to infants and younger children, insofar as they are unable to provide consent. Despite their vulnerability, infants' organs and tissues are considered valuable for biomedical purposes due to their size and unique properties.
View Article and Find Full Text PDF"If you prick us, do we not bleed?" Antisemitism and psychosocial health among Jews in Germany.
Front Psychol
January 2025
Department of Developmental Psychology, Institute for Psychology, Osnabrück University, Osnabrück, Germany.
Introduction: Amid escalating global antisemitism, particularly following the Hamas attack on Israel on October 7, 2023, this study addresses critical gaps in understanding the psychosocial impact of antisemitism on Jewish communities worldwide.
Methods: Focusing on the Jewish community in Germany, we conducted a cross-sectional survey of 420 Jewish individuals (mean age = 40.71 years, SD = 15.
Deciphering the complex molecular architecture of the genetically modified soybean FG72 through paired-end whole genome sequencing.
Food Chem (Oxf)
June 2025
Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China.
The clear molecular characterization of genetically modified (GM) plants and animals is a prerequisite for obtaining regulatory approval and safety certification for commercial cultivation. This characterization includes the identification of the transferred DNA (T-DNA) insertion site, its flanking sequences, the copy number of inserted genes, and the detection of any unintended genomic alterations accompanying the transformation process. In this study, we performed a comprehensive molecular characterization of the well-known GM soybean event FG72 using paired-end whole-genome sequencing (PE-WGS).
View Article and Find Full Text PDFResearch focus and theme evolution on enhanced external counterpulsation: A bibliometric analysis.
Heliyon
January 2025
Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Aims: The study delved into the identification of key research areas and evolving trends within the domain of Enhanced External Counterpulsation, aiming to gain comprehensive insights into the subject matter.
Methods: Utilizing the sophisticated search parameter of 'topic' (TS) on the Web of Science (WoS) database, the necessary information was retrieved. This research employed an array of tools for effective data extraction, analysis, and visualization, which included Microsoft Excel for tabular management, HistCite Pro for citation analysis, GunnMap for geographical mapping, BibExcel for bibliometric assessments, and VOSviewer for network visualization purposes.
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