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Current US prevalence of myocardial injury patterns and clinical outcomes among hospitalised patients with familial hypercholesterolaemia: insight from the National Inpatient Sample-a retrospective cohort study.
BMJ Open
May 2024
Division of Cardiology, John H Stroger Jr Hospital of Cook County, Chicago, Illinois, USA.
Article Synopsis
- Familial hypercholesterolaemia (FH) is linked to an increased risk of heart disease, particularly in patients who experience acute myocardial injury (AMI), but detailed outcomes for these patients have been understudied.
- The research analyzed data from US hospitals between 2018 and 2020, focusing on adults with AMI to compare outcomes based on the presence of FH.
- Findings revealed that FH patients had higher rates of ST-elevation and non-ST-elevation myocardial infarctions, required more invasive procedures, but exhibited lower all-cause mortality and lower incidences of type 2 MI and takotsubo cardiomyopathy compared to those without FH.
Unveiling Familial Hypercholesterolemia-Review, Cardiovascular Complications, Lipid-Lowering Treatment and Its Efficacy.
Int J Mol Sci
January 2024
Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland.
Familial hypercholesterolemia (FH) is a genetic disorder primarily transmitted in an autosomal-dominant manner. We distinguish two main forms of FH, which differ in the severity of the disease, namely homozygous familial hypercholesterolemia (HoFH) and heterozygous familial hypercholesterolemia (HeFH). The characteristic feature of this disease is a high concentration of low-density lipoprotein cholesterol (LDL-C) in the blood.
View Article and Find Full Text PDFSpatial lipidomics of coronary atherosclerotic plaque development in a familial hypercholesterolemia swine model.
J Lipid Res
February 2024
Department of Cardiology, Cardiovascular Institute, Thorax Center, Erasmus MC, Rotterdam, The Netherlands; Department of Precision and Microsystems Engineering, Delft University of Technology, Delft, The Netherlands; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address:
Article Synopsis
- Coronary atherosclerosis is driven by plaque accumulation, with lipids significantly influencing its development, but their specific roles and distributions are not well understood.
- This study uses MALDI-MSI to visualize lipid distributions in different stages of coronary artery disease in hypercholesterolemic swine, classifying segments as healthy, mild, or advanced disease.
- Findings reveal unique lipid profiles and their associations with disease progression, particularly highlighting the relationship of specific lipids with necrotic areas and inflammatory cells in advanced plaques.*
Genetic identification of familial hypercholesterolemia within whole genome sequences in 6820 newborns.
Clin Genet
March 2024
Heart Center, Qingdao Women and Children's Hospital, Qingdao University, Qingdao, China.
Familial hypercholesterolemia (FH) is defined as a monogenic disease, characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels. FH remains underdiagnosed and undertreated in Chinese. We whole-genome sequenced 6820 newborns from Qingdao of China to investigate the FH-related gene (LDLR, APOB, PCSK9) mutation types, carrier ratio and genotype-phenotype correlation.
View Article and Find Full Text PDFLipoprotein(a) as a Risk Factor for Cardiovascular Diseases: Pathophysiology and Treatment Perspectives.
Int J Environ Res Public Health
September 2023
Clinica Medica, Cattinara Hospital, Department of Medical Surgical and Health Science, University of Trieste, 34149 Trieste, Italy.
Cardiovascular disease (CVD) is still a leading cause of morbidity and mortality, despite all the progress achieved as regards to both prevention and treatment. Having high levels of lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease that operates independently. It can increase the risk of developing cardiovascular disease even when LDL cholesterol (LDL-C) levels are within the recommended range, which is referred to as residual cardiovascular risk.
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