One of the children of a t(15;22) (q111;p11) woman has lost the minute metacentric der(15) without any clinical consequence, indicating the inocuity of the 15pter----q111 and 22pter----p11 monosomies. The segregation mechanism of this monosomy and, from this family, the relation between reciprocal translocations and Robertsonian translocations are discussed. Another subject with r(22) in the same family questions on an hypothetic common origin.
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