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An archaeal peptidase assembles into two different quaternary structures: A tetrahedron and a giant octahedron.
J Biol Chem
November 2006
Laboratoire de Virologie Moléculaire et Structurale c/o EMBL, FRE 2854 CNRS-UJF, 38042 Grenoble, France.
Cellular proteolysis involves large oligomeric peptidases that play key roles in the regulation of many cellular processes. The cobalt-activated peptidase TET1 from the hyperthermophilic Archaea Pyrococcus horikoshii (PhTET1) was found to assemble as a 12-subunit tetrahedron and as a 24-subunit octahedral particle. Both quaternary structures were solved by combining x-ray crystallography and cryoelectron microscopy data.
View Article and Find Full Text PDF[Activity of choline esterases in blood cells and serum and cobalt activated acylase in toxic and non-toxic liver damage].
Ann Acad Med Stetin
June 1996
Katedry i Zalładu Medycyny Sadowej Pomorskiej Akademii Medycznej w Szczecinie.
Organic insecticides used in agriculture and drugs often taken without medical control remain an important source of intoxication. The significance of the problem has been discussed in American medical literature, where toxic and posttoxic damage to the liver is rated second (25%), just after viral damage (40%), like in other highly developed countries. It can be assumed that the leading position of viral damage is the result of difficulties in ascertaining the diagnosis in each case of the disease.
View Article and Find Full Text PDF[Certain enzymatic markers of liver damage in poisoning with Amanita phalloides].
Wiad Lek
February 1994
Pracowni Toksykologii Kliniczej Zakładu Biochemii Klinicznej i Diagnostyki Laboratoryjnej Pomorskiej Ak. Med. w Szczecinie.
The activity of selected enzymes was studied in 12 persons on the first day of poisoning with Amanita phalloides. It was found that the most sensitive marker of liver damage was significant increase of activity of cobalt-activated acylase, observed in all studied cases.
View Article and Find Full Text PDF[Morphological and biochemical studies of the effect of the peat-derived preparation PF-290/II/2 on the development of natural lymphatic leukemia in mice].
Pol Arch Weter
October 1988
Katedra Anatomii Patologicznej i Weterynarii Sadowej AR we Wrocławiu.
AKR mice highly susceptible to leukemia were fed orally for 9 months every days with a water solution of peat-liking preparation PF-290/II/2 at a dose 0.2 cm3 (70 g/cm3 water). After bleeding body and internal organs weight were measured and their ratio were calculated.
View Article and Find Full Text PDFActivity of some hydrolases in mice with transplantable lymphatic leukemia P 388.
Folia Histochem Cytobiol
October 1987
Mice--BDF, hybrides, males aged 3 months were injected intraperitoneally with 10(4) lymphatic leukemia cells P 388. The mice were killed by bleeding after 2.5 and 10 days after the injection.
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