Testosterone is able to inhibit the development of tolerance in the smooth muscle of the rat vas deferens. Cycloheximide and actinomycin D also inhibit the tolerance to morphine and ethanol in smooth muscle of rat vas deferens. The toxic effect of cycloheximide and actinomycin D do not play roles in the inhibition of tolerance. The physiological responses of vas deferens to norepinephrine are not altered by cycloheximide and actinomycin D.
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