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Mechanistic insights into drug supersaturation during lipid digestion in self-emulsifying drug delivery systems: A cryo-TEM and NMR study.
Int J Pharm
March 2025
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
A self-emulsifying drug delivery system (SEDDS), composed of oil, surfactant, and co-surfactant, has been widely used to enhance the oral absorption of poorly water-soluble drugs. Upon oral administration, SEDDS spontaneously forms an emulsion upon contact with gastrointestinal fluids, thereby solubilizing the drug within oil droplets. Lipid digestion by lipase further facilitates the release of encapsulated drugs into the aqueous phase, generating drug supersaturation that can enhance absorption.
View Article and Find Full Text PDFImpact of Microemulsion Oil Components on Liquid-Liquid Phase Separation of a Supersaturated Drug Revealed by Cryo-TEM and H NMR Analysis.
Mol Pharm
March 2025
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) has recently been utilized to enhance the oral absorption of poorly water-soluble drugs. S-SMEDDS forms drug-incorporated microemulsions (MEs) during aqueous dispersion with the formation of drug supersaturation in the bulk water phase. However, the liquid-liquid phase separation (LLPS) behavior of the supersaturated drugs within MEs has not been well studied.
View Article and Find Full Text PDFDesigning a contact lens with atropine base using a microemulsion technique.
Cont Lens Anterior Eye
February 2025
School of Optometry and Vision Science, University of New South Wales Sydney NSW Australia.
Purpose: Myopia or near-sightedness is a global vision problem. Atropine eye drops and myopia-controlling contact lenses can help to slow down its progression, but neither is sufficient alone. The present research work was conducted to design a contact lens embedded with an atropine base within a microemulsion system.
View Article and Find Full Text PDFThermodynamic Explanation of Surfactant-Free Microemulsions.
J Phys Chem B
February 2025
Key Laboratory of Colloid & Interface Chemistry (Ministry of Education), Shandong University, Jinan 250100, P.R. China.
There is sufficient evidence to prove that microemulsions can be formed by two immiscible liquids (generally called oil and water components) in the presence of an amphi-solvent rather than traditional surfactants, but how to explain such surfactant-free microemulsions (SFMEs) with thermodynamics is still a challenge. In this work, based on the Flory-Huggins theory, a general thermodynamic principle for SFMEs was established, by assuming SFMEs to be a pseudobinary system consisting of the water-rich and oil-rich components (i.e.
View Article and Find Full Text PDFMicroemulsification-based hybrid oxygenated biofuel for CI engine locomotives: with special reference to "preparation" techniques and "performance" analysis.
Environ Sci Pollut Res Int
January 2025
Mechanical Engineering Department, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
In recent years, rising environmental concerns and the detrimental impact of emissions from the growing number of locomotives have prompted scientists to investigate alternative fuels derived from renewable lipids, such as microemulsion-based hybrid biofuels (MHBFs). Petro crops and lignocellulosic biomass are the common agricultural and forest feedstocks for biofuel production. Biofuel can be characterized in terms of its volatility range, physicochemical properties, composition, combustion, and emission characteristics.
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