It was demonstrated that the physico-chemical properties of human transcortin, i.e., electrophoretic, hydrodynamic and immunochemical characteristics, amino acid composition, steroid binding parameters, do not depend on the source of the glycoprotein (male or female blood, retroplacental blood). Conversely, the retroplacental blood serum was shown to contain a transcortin form whose carbohydrate component is structurally different from that of the normal donor blood transcortin. It was found that this form interacts with the sites of specific binding of transcortin in liver cell plasma membranes in a weaker degree than the donor blood transcortin.
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