Several new derivatives of 5-aminomethyl-6-/p-chlorophenyl/-4, 5-dihydro-2H-pyridazin-3-one have been obtained. The substrates, beta-aminomethyl-beta-/p-chlorobenzoyl/-propionic acid derivatives 1-5, were converted by reactions with hydrazine hydrate or monosubstituted hydrazines, i.e. phenylhydrazine and N-/beta-hydroxyethyl/-hydrazine into appropriate derivatives of 5-aminomethyl-6-/p-chlorophenyl/-4,5-dihydro-2H-pyridazin-3-one 6-18. Compounds 7, 8, 11, 12, 14, 15, and 18 show depressant activity on CNS, while compounds 7a, 9a, 10, 11, 14, 15 possess cytostatic and immunosuppressive activities.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
investigations derivatives
4
derivatives 5-aminomethyl-6-/p-chloro-phenyl/-4
4
5-aminomethyl-6-/p-chloro-phenyl/-4 5-dihydro-2h-pyridazin-3-one
4
5-dihydro-2h-pyridazin-3-one derivatives
4
derivatives 5-aminomethyl-6-/p-chlorophenyl/-4
4
5-aminomethyl-6-/p-chlorophenyl/-4 5-dihydro-2h-pyridazin-3-one
4
5-dihydro-2h-pyridazin-3-one substrates
4
substrates beta-aminomethyl-beta-/p-chlorobenzoyl/-propionic
4
beta-aminomethyl-beta-/p-chlorobenzoyl/-propionic acid
4
acid derivatives
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!