Oxygen requirement and supply (RS) of the myocardium were studied in 232 patients with coronary heart disease during an angina pectoris (AP) attack provoked by bicycle ergometry. It was discovered that an attack of stable AP occurs approximately at the same level of the RS tension in all the functional classes of AP. This level correlates with the RS tension in normal subjects exposed to submaximal exercise. The lower the functional class of AP the less or even negligible are the levels at which the RS tension is high. The following varieties of cardiohemodynamic (CHD) disturbances leading to inadequacy were revealed: tachycarditic, hypertensive, hypodiastolic. The adequate type of the CHD response was often observed in unstable angina pectoris. In stable AP, the deterioration was accompanied by inadequacy augmentation, whereas in the adequate type, the improvement or remission led to the appearance of an AP attack at the height of the RS tension. It is assumed that the adequate type of the CHD response is linked somehow with the diffuse spastic reaction of heart vessels.
Download full-text PDF |
Source |
---|
Mol Neurodegener
January 2025
The Picower Institute for Learning and Memory, Cambridge, MA, USA.
Many diseases and disorders of the nervous system suffer from a lack of adequate therapeutics to halt or slow disease progression, and to this day, no cure exists for any of the fatal neurodegenerative diseases. In part this is due to the incredible diversity of cell types that comprise the brain, knowledge gaps in understanding basic mechanisms of disease, as well as a lack of reliable strategies for delivering new therapeutic modalities to affected areas. With the advent of single cell genomics, it is now possible to interrogate the molecular characteristics of diverse cell populations and their alterations in diseased states.
View Article and Find Full Text PDFPLoS One
January 2025
Nivel, Netherlands Institute for Health Services Research, Utrecht, The Netherlands.
Background: Some of those infected with SARS-CoV-2 suffer from post-COVID syndrome (PCS). However, an uniform definition of PCS is lacking, causing uncertainty about the prevalence and nature of this syndrome. We aimed to improve understanding of PCS by operationalizing different classifications and to explore clinical subtypes.
View Article and Find Full Text PDFClin Endocrinol (Oxf)
January 2025
Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, 3004, VIC, Australia.
Objective: To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT).
Design: The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data.
Patients: The review focuses on MHT-related outcomes in women with natural-timed menopause captured within observational studies, RCTs, and pooled data from pivotal meta-analyses and reviews.
Acta Otolaryngol
January 2025
Department of Otorhinolaryngology, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Background: Countries need information about epidemiology of hearing loss along the lifespan to develop adequate health policies.
Objectives: Estimate prevalence of hearing loss in children six years old in the south-west area Santiago, Chile, and estimate incidence of late-onset hearing loss for the same population. Secondary objective: explore risk factors associated with hearing loss.
mSystems
January 2025
Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Gluconeogenesis, the reciprocal pathway of glycolysis, is an energy-consuming process that generates glycolytic intermediates from non-carbohydrate sources. In this study, we demonstrate that robust and efficient gluconeogenesis in bacteria relies on the allosteric inactivation of pyruvate kinase, the enzyme responsible for the irreversible final step of glycolysis. Using the model bacterium as an example, we discovered that pyruvate kinase activity is inhibited during gluconeogenesis via its extra C-terminal domain (ECTD), which is essential for autoinhibition and metabolic regulation.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!