Based on the clinical, experimental and biomechanical studies the authors suggest intraarticular treatment of rheumatoid arthritis (RA) and deforming osteoarthrosis (DOA) by means of artificial synovial fluid (ASF) developed with the use of polymers and biopolymers. Rheological studies performed with the use of a Rheotest-2 apparatus and ultrasonic interferometry of the samples of normal, RA, DOA synovial fluid and ASF demonstrated that medium-molecular-weight polyvinylpyrrolidone (PVP) and PVP hyaluronate appeared the most similar to natural synovial fluid, PVP-hyaluronate, PVP and its complexes with other drugs (cyclophosphamide, hydrocortisone, arteparone) were applied intraarticularly to the treatment of 520 patients with RA and DOA. The group of patients who received kenalog or placebo intraarticularly served as control. Over 3000 intraarticular administrations of ASF and its complexes were made altogether. No side effects were observed. In the articular medium, PVP displayed lubrication, anti-inflammatory, prolonging, anticommissural and other effects. Attention is drawn to the immunoregulatory action of PVP. The treatment with artificial articular lubricants promoted the improvement of the function of the joints and positive time-course of some clinical, laboratory, biochemical and immunological characteristics.
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ACS Appl Bio Mater
January 2025
Department of Materials Engineering, Indian Institute of Science Bangalore, Karnataka 560012, India.
The cartilage possesses limited regenerative capacity, necessitating advanced approaches for its repair. This study introduces a bioink designed for cartilage tissue engineering (TE) by incorporating ionically cross-linkable alginate into the photo-cross-linkable MuMA bioink, resulting in a double cross-linked interpenetrating network (IPN) hydrogel. Additionally, hyaluronic acid (HA), a natural component of cartilage and synovial fluid, was added to enhance the scaffold's properties.
View Article and Find Full Text PDFAnn Transl Med
December 2024
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Background: Osteoarthritis (OA) is increasingly thought to be a multifactorial disease in which sustained gut inflammation serves as a continued source of inflammatory mediators driving degenerative processes at distant sites such as joints. The objective of this study was to use the equine model of naturally occurring obesity associated OA to compare the fecal microbiome in OA and health and correlate those findings to differential gene expression synovial fluid (SF) cells, circulating leukocytes and cytokine levels (plasma, SF) towards improved understanding of the interplay between microbiome and immune transcriptome in OA pathophysiology.
Methods: Feces, peripheral blood mononuclear cells (PBMCs), and SF cells were isolated from healthy skeletally mature horses (n=12; 6 males, 6 females) and those with OA (n=6, 2 females, 4 males).
Commun Biol
January 2025
Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Protein citrullination modification plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA), and anti-citrullinated protein antibodies (ACPAs) are extensively employed for clinical diagnosis of RA. However, there remains limited understanding regarding specific citrullinated proteins and their implications in the progression of RA. In this study, we screen and verify insulin-like growth factor-2 mRNA binding protein 1 (IGF2BP1) as a novel citrullinated protein with significantly elevated citrullinated level in RA.
View Article and Find Full Text PDFIDCases
December 2024
Maimonides Medical Center, Brooklyn, NY, USA.
An 85-year-old woman with a history of total knee replacements for osteoarthritis in the past, presented with left knee swelling and pain that persisted for 14 months. An initial diagnosis of synovial cyst was made, and she underwent multiple aspirations and symptomatic treatments without improvement. Repeat arthrocentesis showed a WBC of 56,000/μL with 61 % neutrophils and 34 % lymphocytes.
View Article and Find Full Text PDFNative joint septic arthritis (SA) is a severe, potentially life-threatening condition characterized by the invasion of synovial fluid and membrane by pathogens, most commonly bacteria. The rising frequency of intra-articular procedures such as joint aspirations and injections has led to increased concern regarding iatrogenic septic arthritis. This mini-review aims to summarize current understanding of the incidence, risk factors, bacterial etiology, and strategies for preventing SA associated with intra-articular procedures.
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